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海参五角瓜中两种新的硫酸化三萜糖苷——菲林诺普西德E和F。

Philinopsides E and F, two new sulfated triterpene glycosides from the sea cucumber Pentacta quadrangularis.

作者信息

Zhang Shi-Long, Li Ling, Yi Yang-Hua, Sun Peng

机构信息

Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P.R. China.

出版信息

Nat Prod Res. 2006 Apr;20(4):399-407. doi: 10.1080/14786410500185584.

DOI:10.1080/14786410500185584
PMID:16644536
Abstract

Two new sulfated triterpene glycosides, philinopside E (1) and F (2), have been isolated from the sea cucumber Pentacta quadrangularis. Their structures have been established by extensive spectral analysis (NMR and MS) and chemical evidence. Glycoside 1 showed significant cytotoxicity (Ed(50) 0.75-3.50 microg mL(-1)) against ten tumor cell lines.

摘要

从四角五角瓜参中分离出了两种新的硫酸化三萜糖苷，即海参皂苷E（1）和F（2）。它们的结构已通过广泛的光谱分析（核磁共振和质谱）及化学证据得以确定。糖苷1对十种肿瘤细胞系显示出显著的细胞毒性（半数有效剂量为0.75 - 3.50微克/毫升）。

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