Golomb H M, Rowley J, Vardiman J, Baron J, Locker G, Krasnow S
Arch Intern Med. 1976 Jul;136(7):825-8.
Two patients with acute promyelocytic leukemia had an identical chromosomal abnormality detected by fluoresecence banding. In each case, the clinical course was rapidly fatal, and was characterized by a lack of response to chemotherapy with cytarabine and thioguanine, and was complicated by disseminated intravascular coagulation. Bone marrow cells from each patient contained 46 chromosomes; in each instance, however, one chromosome 17 had a deletion of almost one half of the proximal portion of the long arm [del(17)(q11q21 or 22)].
两名急性早幼粒细胞白血病患者通过荧光带型检测到相同的染色体异常。在每例患者中，临床病程进展迅速且致命，其特点是对阿糖胞苷和硫鸟嘌呤化疗无反应，并伴有弥散性血管内凝血。每位患者的骨髓细胞均含有46条染色体；然而，在每例患者中，一条17号染色体的长臂近端几乎一半发生缺失[del(17)(q11q21或22)]。
