P300与眨眼指令。
P300 and blink instructions.
作者信息
Ochoa C J, Polich J
机构信息
Department of Psychology, University of California, San Diego, La Jolla 92037, USA.
出版信息
Clin Neurophysiol. 2000 Jan;111(1):93-8. doi: 10.1016/s1388-2457(99)00209-6.
OBJECTIVES
The effects of instructions to refrain from blinking on the P300 event-related brain potential (ERP) from auditory and visual stimuli were assessed.
METHODS
An oddball paradigm was employed in which young adult subjects (n = 20) silently counted the infrequent target stimuli and were given either no instructions or told "do not blink" in different conditions, with auditory and visual stimulus tasks employed for all subjects. ERPs were recorded from the midline electrodes, with amplitude and latency of the P300 and other components obtained.
RESULTS
P300 amplitude for both modalities and target/standard stimulus conditions was smaller and visual peak latency longer in the "do not blink" condition. Blink instructions did not directly affect the other components.
CONCLUSIONS
Instructions to refrain from blinking can decrease P300 amplitude and can increase peak latency.
目的
评估抑制眨眼的指令对听觉和视觉刺激诱发的P300事件相关脑电位（ERP）的影响。
方法
采用oddball范式，年轻成年受试者（n = 20）在不同条件下对罕见的目标刺激进行默数，要么不给予指令，要么被告知“不要眨眼”，所有受试者都进行听觉和视觉刺激任务。从中线电极记录ERP，获取P300及其他成分的幅度和潜伏期。
结果
在“不要眨眼”条件下，两种刺激方式以及目标/标准刺激条件下的P300幅度均较小，视觉峰值潜伏期更长。眨眼指令并未直接影响其他成分。
结论
抑制眨眼的指令可降低P300幅度并增加峰值潜伏期。
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