Leteurtre E, Brami F, Kerr-Conte J, Quandalle P, Lecomte-Houcke M
Anatomie et Cytologie Pathologiques A, Faculté de Médecine.
Arch Pathol Lab Med. 2000 Feb;124(2):284-6. doi: 10.5858/2000-124-0284-MDECOT.
We describe herein a case of a mixed ductal-endocrine pancreatic carcinoma. Rare cases of mixed pancreatic tumors have been described, with endocrine and exocrine components each making up a significant proportion of the neoplasm; to our knowledge, only one case has been reported with a mixed liver metastasis. In our case, ductal and endocrine cells were intimately admixed in the primary tumor and in a peripancreatic lymph node metastasis, diagnosed by standard light microscopy and double immunostaining for cytokeratin 19 and synaptophysin. The endocrine component was immunoreactive for somatostatin. Tumors with admixed endocrine and exocrine components support the hypothesis of a common endodermal histogenesis for the ductal and endocrine cells in the human pancreas.
我们在此描述一例混合性导管-内分泌胰腺癌病例。混合性胰腺肿瘤的罕见病例已有报道，其中内分泌和外分泌成分在肿瘤中各占相当比例；据我们所知，仅有一例伴有混合性肝转移的病例报道。在我们的病例中，通过标准光学显微镜以及细胞角蛋白19和突触素的双重免疫染色，在原发性肿瘤及胰周淋巴结转移灶中均发现导管细胞和内分泌细胞紧密混合。内分泌成分对生长抑素呈免疫反应性。内分泌和外分泌成分混合的肿瘤支持人类胰腺中导管细胞和内分泌细胞具有共同内胚层组织发生学的假说。
