Malon Adam, Brockmann Christian, Fijalkowska-Morawska Jolanta, Rob Peter, Maj-Zurawska Magdalena
Faculty of Chemistry, Warsaw University, Pasteura 1, 02093 Warsaw, Poland.
Clin Chim Acta. 2004 Nov;349(1-2):67-73. doi: 10.1016/j.cccn.2004.06.006.
Almost 99% of the body magnesium is inside cells. The concentration of intracellular ionized magnesium (iMg) is physiologically relevant. iMg in erythrocytes is a new parameter that can help to establish reliable information on the functional magnesium status.
iMg concentration in erythrocytes and serum was measured by ion-selective electrode, in clinical analyzer Microlyte (KONE). Total magnesium (tMg) concentration was measured by atomic absorption spectrometry (AAS). Albumin and total protein concentration were measured colorimetrically.
In critically ill postoperative patients, the mean of albumin, protein and hematocrit concentration was significantly lower compared to healthy individuals. Hypomagnesemia was found in 15.9% patients as tMgs, at 22.2% as iMgs and 36.5% as iMge. Significant correlations are between iMgs and tMgs or iMge and iMgs/tMgs. In dialyzed patients, the mean of hematocrit was significantly lower, iMge was significantly higher compared with healthy individuals. Significant negative correlations are between iMgs and tMge or iMge/tMge and tMge.
iMge is the best magnesium parameter to observe hypo- or hypermagnesemia for both groups of patients. The function of magnesium is mainly intracellular and intracellular magnesium concentrations can be the method to evaluate the magnesium status.
人体近99%的镁存在于细胞内。细胞内游离镁（iMg）的浓度具有生理相关性。红细胞内的iMg是一个新参数，有助于建立关于功能性镁状态的可靠信息。
采用离子选择性电极在临床分析仪Microlyte（芬兰康尔公司）上测量红细胞和血清中的iMg浓度。采用原子吸收光谱法（AAS）测量总镁（tMg）浓度。采用比色法测量白蛋白和总蛋白浓度。
与健康个体相比，危重症术后患者的白蛋白、蛋白质和血细胞比容浓度平均值显著降低。15.9%的患者存在低镁血症（以tMg计），22.2%以iMg计，36.5%以iMge计。iMgs与tMgs之间、iMge与iMgs/tMgs之间存在显著相关性。在透析患者中，血细胞比容平均值显著降低，iMge显著高于健康个体。iMgs与tMge之间、iMge/tMge与tMge之间存在显著负相关。
对于两组患者，iMge是观察低镁血症或高镁血症的最佳镁参数。镁的功能主要在细胞内，细胞内镁浓度可作为评估镁状态的方法。
