Gilliland F D, Linn W, Rappaport E, Avol E, Gong H, Peters J
University of Southern California, School of Medicine, Department of Preventive Medicine, Los Angeles 90033, USA.
Occup Environ Med. 1999 Oct;56(10):718-20. doi: 10.1136/oem.56.10.718.
To assess the magnitude of error in pulmonary function measurements introduced by variation in spirometer temperature under field conditions. In a large scale epidemiological study of school children, the influence was investigated of spirometer temperature on forced expiratory volume in 1 second (FEV1) measured with dry rolling seal volumetric spirometers and conventional body temperature, pressure, and saturation (BTPS) corrections.
Linear regression analyses were performed on data from 995 test-retest pairs on 851 different children, with 1-110 days between test and retest, and spirometer temperature differences between -13 degrees C and +9 degrees C.
After adjusting for effects of growth (test-retest intervals) and circadian variation (changes in times of testing), differences in standard BTPS corrected FEV1 showed significant (p < 0.05) dependence on differences in spirometer temperature between tests (-0.24%/degree C).
When spirometer temperatures vary widely, standard BTPS correction does not fully adjust for gas contraction. To improve accuracy of volume measurements in epidemiological studies, additional correction for variation in spirometer temperature should be considered.
评估在现场条件下，肺活量计温度变化所导致的肺功能测量误差的大小。在一项针对学龄儿童的大规模流行病学研究中，调查了肺活量计温度对使用干式滚动密封容积式肺活量计测量的1秒用力呼气量（FEV1）以及传统体温、压力和饱和状态（BTPS）校正的影响。
对来自851名不同儿童的995对重测数据进行线性回归分析，测试与重测之间间隔1至110天，肺活量计温度差异在-13摄氏度至+9摄氏度之间。
在调整生长（测试-重测间隔）和昼夜变化（测试时间变化）的影响后，标准BTPS校正的FEV1差异显示出对测试之间肺活量计温度差异具有显著（p < 0.05）依赖性（-0.24%/摄氏度）。
当肺活量计温度变化很大时，标准BTPS校正不能完全校正气体收缩。为提高流行病学研究中容积测量的准确性，应考虑对肺活量计温度变化进行额外校正。
