Warshaw A L, Lee K H, Wood W C, Cohen A M
Am J Surg. 1980 Jan;139(1):27-32. doi: 10.1016/0002-9610(80)90225-1.
The serum levels of a poly-[C]-specific acid ribonuclease (RNase) found in the pancreas was measured in 40 normal persons and 137 patients with pancreatic cancer, other cancers, obstructive jaundice, acute pancreatitis or chronic pancreatitis. Serum RNase increased by as much as 800 percent above normal in 69 percent of patients with pancreatic cancer. Analysis of the serum isoenzymes of RNase by isoelectric focusing did not reveal any unique RNases produced by the tumours. In contrast, serum RNase rose in only 8 percent of patients with other cancers, 11 percent of other patients with obstructive jaundice and in no patients with chronic pancreatitis. These data suggest that the finding of increased serum RNase is of adjunctive value inthe diagnosis of pancreatic carcinoma and may be particularly helpful in distinguishing it from other causes of biliary obstruction and from chronic pancreatitis.
在40名正常人以及137名患有胰腺癌、其他癌症、阻塞性黄疸、急性胰腺炎或慢性胰腺炎的患者中，检测了胰腺中发现的一种聚[C]特异性酸性核糖核酸酶（RNase）的血清水平。69%的胰腺癌患者血清RNase比正常水平升高多达800%。通过等电聚焦分析RNase的血清同工酶，未发现肿瘤产生任何独特的RNase。相比之下，其他癌症患者中只有8%的人血清RNase升高，阻塞性黄疸患者中有11%的人血清RNase升高，而慢性胰腺炎患者中无人血清RNase升高。这些数据表明，血清RNase升高这一发现对胰腺癌的诊断具有辅助价值，可能特别有助于将其与其他胆道梗阻原因以及慢性胰腺炎区分开来。
