高压对红细胞磷酸盐转运的抑制作用。
Inhibition of erythrocyte phosphate transport by high pressures.
作者信息
Murphy R B, Libby W F
出版信息
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2767-9. doi: 10.1073/pnas.73.8.2767.
Abstract
Pressures of 200-1000 atmospheres (20-100 MPa) are found to decrease significantly the amount of phosphate (H32PO4-2)transported into the rabbit erythrocyte under otherwise physiological conditions. Such compression does not cause irreversible morphological changes or result in membrane disruption. The findings are interpreted in terms of a lipid phase transition induced by the high pressure, which is propagated to the associated phosphate transport system by a physical mechanism.
摘要
发现在200 - 1000个大气压（20 - 100兆帕）的压力下，在其他方面为生理条件的情况下，进入兔红细胞的磷酸盐（H₃²PO₄⁻²）的量会显著减少。这种压缩不会引起不可逆的形态变化或导致膜破裂。这些发现是根据高压诱导的脂质相变来解释的，这种相变通过物理机制传播到相关的磷酸盐转运系统。
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