Lindeman R D, Romero L J, Koehler K M, Liang H C, LaRue A, Baumgartner R N, Garry P J
Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque 87131-5271, USA.
J Am Coll Nutr. 2000 Feb;19(1):68-76. doi: 10.1080/07315724.2000.10718916.
Equal numbers of male and female Hispanics and NHW were randomly sampled from the Health Care Financing Administration (Medicare) registrant list for Bernalillo County, New Mexico, and asked to volunteer for a paid home interview followed by a paid comprehensive interview/examination covering health and health-related issues. In addition to serum determinations of B12, C and folate, associations were examined between these vitamins and measures of cognitive and affective functions.
Males and Hispanics had lower serum vitamin B12, C and folate concentrations than females and NHW respectively. Participants taking a multivitamin supplement (MVI) had higher serum vitamin concentrations than those not taking MVI. There were significant associations between serum folate concentrations and measures of cognitive function, not seen with B12 or C, nor between any of the vitamins and affective function.
Hispanics, even after adjustments for gender, age, vitamin supplementation, vitamin content of dietary foods, education and household income, had lower serum concentrations of B12, C and folate than NHW. The most significant associations observed were those between serum folate and various measures of cognitive function, even after adjusting for presence of depression.
1）比较随机抽取的65岁及以上西班牙裔和非西班牙裔白人（NHW）老年男性和女性的血清维生素B12、C和叶酸浓度；2）研究血清B12、C和叶酸浓度与认知和情感（抑郁）功能指标之间的关联。
从新墨西哥州伯纳利欧县医疗保健财务管理局（医疗保险）登记名单中随机抽取数量相等的西班牙裔和非西班牙裔白人男性和女性，并邀请他们自愿参加有偿的家庭访谈，随后参加涵盖健康及与健康相关问题的有偿综合访谈/检查。除了测定血清中的B12、C和叶酸外，还研究了这些维生素与认知和情感功能指标之间的关联。
男性和西班牙裔的血清维生素B12、C和叶酸浓度分别低于女性和非西班牙裔白人。服用多种维生素补充剂（MVI）的参与者血清维生素浓度高于未服用MVI的参与者。血清叶酸浓度与认知功能指标之间存在显著关联，而B12或C与认知功能指标之间以及任何一种维生素与情感功能之间均未观察到这种关联。
即使在对性别、年龄、维生素补充、膳食食物中的维生素含量、教育程度和家庭收入进行调整之后，西班牙裔的血清B12、C和叶酸浓度仍低于非西班牙裔白人。观察到的最显著关联是血清叶酸与各种认知功能指标之间的关联，即使在对抑郁症的存在进行调整之后也是如此。
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