丙泊酚麻醉对接受电休克治疗患者认知恢复的影响。
Effects of propofol anesthesia on cognitive recovery of patients undergoing electroconvulsive therapy.
作者信息
Sakamoto A, Hoshino T, Suzuki N, Suzuki H, Kimura M, Ogawa R
机构信息
Department of Anesthesiology, Nippon Medical School, Tokyo, Japan.
出版信息
Psychiatry Clin Neurosci. 1999 Dec;53(6):655-60. doi: 10.1046/j.1440-1819.1999.00621.x.
The effects of different doses of propofol on post-electroconvulsive therapy (ECT) cognitive recovery were evaluated together with the effects on seizure duration and hemodynamic changes during ECT in 15 depressive patients. Propofol attenuated the increase in arterial blood pressure and heart rate in a dose-dependent manner compared with thiamylal. Propofol showed a clinically significant anticonvulsant effect during ECT in a dose-dependent manner. There were no significant differences among the four different induction groups in the mean recovery time from anesthesia, however, a low dose of propofol suppressed the early recovery of cognitive function. For early cognitive recovery after ECT, a deep anesthetic level is necessary when the traditional ECT apparatus is used which produces sine curve wave stimuli.
在15例抑郁症患者中，评估了不同剂量丙泊酚对电休克治疗（ECT）后认知恢复的影响，以及对ECT期间癫痫发作持续时间和血流动力学变化的影响。与硫喷妥钠相比，丙泊酚以剂量依赖的方式减弱了动脉血压和心率的升高。丙泊酚在ECT期间以剂量依赖的方式显示出具有临床意义的抗惊厥作用。四个不同诱导组在麻醉后平均恢复时间上没有显著差异，然而，低剂量丙泊酚抑制了认知功能的早期恢复。对于ECT后的早期认知恢复，当使用产生正弦曲线波刺激的传统ECT设备时，需要较深的麻醉水平。
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