Saxén L, Harjola O, Ainamo J
J Clin Periodontol. 1976 Nov;3(4):195-9. doi: 10.1111/j.1600-051x.1976.tb00038.x.
An experimental study was designed to compare the claimed antibacterial effect of Betadine and Blend-a-med Fluid with the known plaque growth inhibiting effect of a 0.2% aqueous solution of chlorhexidine digluconate (Hibitane). Before the test perios for 5 days. During the following week they cleaned their teeth mechanically with toothbrush and toothpicks. For the third week the students were divided into three experimental groups. Following closely the manufacturers' recommendations, one group rinsed their mouths four times daily with 10 ml of Betadine, one group every 2 hours with a glassful of water containing 5-8 drops of Blend-a-med Fluid, and the control group twice daily with 10 ml of the 0.2% chlorhexidine solution. Mechanical cleaning of the teeth was not allowed during the experimental week. The Plaque Index scorings decreased significantly from the end of the no-hygiene to the end of the mechanical cleaning period. During the experimental period a further decrease of the mean P1I scores returned to the level recorded after the no-hygiene period. As neither Betadine nor Blend-a-med Fluid proved able to prevent plaque growth in vivo, there seems to be no indication for their use in treatment of gingivitis.
设计了一项实验研究，以比较碘伏和混合医疗液所宣称的抗菌效果与已知的葡萄糖酸洗必泰（洗必泰）0.2%水溶液的牙菌斑生长抑制效果。在测试前的5天里，他们未进行口腔卫生清洁。在接下来的一周，他们用牙刷和牙签进行机械洁牙。在第三周，学生们被分为三个实验组。严格按照制造商的建议，一组每天用10毫升碘伏漱口4次，一组每2小时用一杯含有5 - 8滴混合医疗液的水漱口，对照组每天用10毫升0.2%洗必泰溶液漱口2次。在实验周期间不允许进行机械洁牙。从无口腔卫生清洁结束到机械清洁期结束，菌斑指数评分显著下降。在实验期间，平均菌斑指数（PI）评分进一步下降，之后又恢复到无口腔卫生清洁期记录的水平。由于碘伏和混合医疗液在体内均未证明能够预防牙菌斑生长，因此似乎没有迹象表明它们可用于治疗牙龈炎。
