Muanza K, Traoré B, Gay F, Krudsood S, Danis M, Looareesuwan S
Service de Parasitologie-INSERM U313, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Ann Trop Med Parasitol. 1999 Jul;93(5):449-55. doi: 10.1080/00034989958186.
The kinetic profiles of soluble chondroitin-sulphate A (CSA), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and E-selectin were investigated in 17 patients hospitalized with Plasmodium falciparum malaria. The aim was to see if these circulating adhesion molecules could be considered as markers for the severity of P. falciparum malaria. The levels of all the adhesion molecules were found to be higher in the sera from all the malaria cases, both severe and uncomplicated, than in those from uninfected controls. The elevation in plasma CSA, reported for the first time, was statistically very significant (P = 0.00001). However, when severe cases were compared with the uncomplicated, there were no significant differences in the level of any of the receptors except ICAM-1, which was highest in those with the severe disease (P = 0.01). The absence of any significant correlation between the plasma concentration of CSA and malaria severity indicates that this adhesion molecule could not be used to predict the severity of malaria, although its role in sequestration of the parasites in pregnant women is well established.
对17例因恶性疟原虫疟疾住院的患者的可溶性硫酸软骨素A（CSA）、细胞间黏附分子1（ICAM-1）、血管细胞黏附分子1（VCAM-1）和E-选择素的动力学概况进行了研究。目的是了解这些循环黏附分子是否可被视为恶性疟原虫疟疾严重程度的标志物。发现所有疟疾病例（包括重症和非重症）血清中所有黏附分子的水平均高于未感染对照组。首次报道的血浆CSA升高在统计学上非常显著（P = 0.00001）。然而，将重症病例与非重症病例进行比较时，除ICAM-1外，其他任何受体的水平均无显著差异，ICAM-1在重症患者中最高（P = 0.01）。血浆CSA浓度与疟疾严重程度之间不存在任何显著相关性，这表明尽管该黏附分子在孕妇体内寄生虫滞留中的作用已得到充分证实，但它不能用于预测疟疾的严重程度。
