Sharma A, Kharb S, Chugh S N, Kakkar R, Singh G P
Department of Biochemistry, Postgraduate Institute of Medical Sciences, Rohtak, India.
Ann Nutr Metab. 2000;44(1):11-3. doi: 10.1159/000012815.
Thirty patients with non-insulin-dependent diabetes mellitus were selected for the study. 15 age-matched healthy volunteers served as controls. Serum malonaldehyde, total glutathione, and vitamin E levels were estimated before and after glycemic control and after 4 weeks of vitamin E supplementation. Both total glutathione and vitamin E levels increased after glycemic control and showed an increase after vitamin E supplementation. Malonaldehyde levels lowered after glycemic control, but remained higher than controls. Since vitamin E supplementation significantly decreased oxidative stress in the present study, it may play a role in reducing free-radical-induced oxidant injury in diabetes mellitus.
