Zoratti R, Godsland I F, Chaturvedi N, Crook D, Crook D, Stevenson J C, McKeigue P M
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK.
Metabolism. 2000 Feb;49(2):245-52. doi: 10.1016/s0026-0495(00)91507-5.
Afro-Caribbean men in the United Kingdom have a favorable lipoprotein profile and are at low risk of coronary heart disease (CHD) compared with Europeans and South Asians, but are at high risk of non-insulin-dependent diabetes mellitus (NIDDM) compared with Europeans. To investigate these differences, a cross-sectional comparison was undertaken for measures of lipoprotein metabolism, body composition, and insulin's glucoregulatory and antilipolytic actions in 92 healthy men (42 to 61 years) of Afro-Caribbean, South Asian, or European origin. Afro-Caribbean men were more insulin-resistant than Europeans (insulin sensitivity [Si], 1.96 v3.01 min(-1) x microU(-1) x mL, P < .01). They nevertheless had a more favorable lipoprotein profile, with lower levels of very-low-density lipoprotein (VLDL) cholesterol (0.21 v 0.40 mmol/L, P < .01) and triglycerides (0.34 v 0.74 mmol/L, P < .01), lower serum total triglycerides, higher high-density lipoprotein 2 (HDL2) cholesterol, and larger low-density lipoprotein (LDL) particle size. These differences were not accounted for by differences in nonesterified fatty acid (NEFA) levels, the sensitivity of suppression of NEFA levels to insulin, or body composition. South Asians were also more insulin-resistant than Europeans but had a less favorable lipoprotein profile. Afro-Caribbean men in the United Kingdom are as insulin-resistant as South Asian men but less susceptible to the lipid disturbances that characteristically accompany insulin resistance. This favorable lipid pattern may relate to more effective VLDL metabolism rather than a reduced supply of NEFA as substrate for triglyceride synthesis.
与欧洲人和南亚人相比，英国的非洲裔加勒比男性具有良好的脂蛋白谱，患冠心病（CHD）的风险较低，但与欧洲人相比，患非胰岛素依赖型糖尿病（NIDDM）的风险较高。为了研究这些差异，对92名年龄在42至61岁之间、分别具有非洲裔加勒比、南亚或欧洲血统的健康男性进行了脂蛋白代谢、身体成分以及胰岛素的葡萄糖调节和抗脂解作用的横断面比较。非洲裔加勒比男性比欧洲人更具胰岛素抵抗性（胰岛素敏感性[Si]，1.96对3.01 min(-1)×microU(-1)×mL，P<.01）。然而，他们的脂蛋白谱更有利，极低密度脂蛋白（VLDL）胆固醇水平较低（0.21对0.40 mmol/L，P<.01），甘油三酯水平较低（0.34对0.74 mmol/L，P<.01），血清总甘油三酯较低，高密度脂蛋白2（HDL2）胆固醇较高，低密度脂蛋白（LDL）颗粒较大。这些差异不能用非酯化脂肪酸（NEFA）水平、NEFA水平对胰岛素抑制的敏感性或身体成分的差异来解释。南亚人也比欧洲人更具胰岛素抵抗性，但脂蛋白谱较差。英国的非洲裔加勒比男性与南亚男性一样具有胰岛素抵抗性，但较少受到胰岛素抵抗典型伴随的脂质紊乱的影响。这种有利的脂质模式可能与更有效的VLDL代谢有关，而不是与作为甘油三酯合成底物的NEFA供应减少有关。
