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一名70岁男性,因乳糜泻出现单纯体重减轻和类糙皮病综合征。

A 70-year-old man with isolated weight loss and a pellagra-like syndrome due to celiac disease.

作者信息

Schattner A

机构信息

Department of Medicine, Stanford University School of Medicine, California, USA.

出版信息

Yale J Biol Med. 1999 Jan-Feb;72(1):15-8.

Abstract

An elderly man was diagnosed with celiac disease, which presented with three notable features: first, presentation at the age of 70 with no prior gastrointestinal symptomatology or positive family history; second, triggering of all symptoms following recent myocardial infarction and infective endocarditis; third, presentation with marked (more than 20 percent) weight loss and pellagra-like skin lesions despite nearly normal examination and laboratory tests. Thus, celiac disease may present as a pellagra-like syndrome in the elderly with predominant weight loss that is enhanced by the related taste disturbances.

摘要

一名老年男性被诊断为乳糜泻,该病有三个显著特征:其一,70岁发病,此前无胃肠道症状或家族病史阳性;其二,近期心肌梗死和感染性心内膜炎后引发所有症状;其三,尽管检查和实验室检查基本正常,但仍出现显著(超过20%)体重减轻和糙皮病样皮肤病变。因此,乳糜泻在老年人中可能表现为以体重减轻为主的糙皮病样综合征,相关味觉障碍会加重这种体重减轻。

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本文引用的文献

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Coeliac disease in the elderly.老年人的乳糜泻
Gut. 1994 Jan;35(1):65-7. doi: 10.1136/gut.35.1.65.
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Is coeliac disease underdiagnosed?乳糜泻是否诊断不足?
Br Med J. 1980 Nov 8;281(6250):1258-60. doi: 10.1136/bmj.281.6250.1258.
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Involuntary weight loss: diagnostic and prognostic significance.
Ann Intern Med. 1981 Nov;95(5):568-74. doi: 10.7326/0003-4819-95-5-568.
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The immunology of coeliac disease.乳糜泻的免疫学
Springer Semin Immunopathol. 1990;12(2-3):219-29. doi: 10.1007/BF00197507.

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