Digestive Physiopathology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.
Dermatology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.
Medicina (Kaunas). 2019 Sep 9;55(9):578. doi: 10.3390/medicina55090578.
Celiac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine and is characterized by atrophy of intestinal villi. The manifestations of the disease improve following a gluten-free diet (GFD). CD is associated with various extra-intestinal diseases. Several skin manifestations are described in CD patients. The present paper reviews all CD-associated skin diseases reported in the literature and tries to analyze the pathogenic mechanisms possibly involved in these associations. Different hypotheses have been proposed to explain the possible mechanisms involved in every association between CD and cutaneous manifestations. An abnormal small intestinal permeability seems to be implicated in various dermatological manifestations. However, most of the associations between CD and cutaneous diseases is based on case reports and case series and a few controlled studies. To better assess the real involvement of the cutaneous district in CD patients, large multicentric controlled clinical trials are required.
乳糜泻(CD)是一种自身免疫性肠病,主要影响小肠,其特征是肠绒毛萎缩。无麸质饮食(GFD)可改善疾病表现。CD 与各种肠外疾病有关。CD 患者有多种皮肤表现。本文综述了文献中报道的所有与 CD 相关的皮肤疾病,并试图分析这些关联中可能涉及的发病机制。不同的假说被提出以解释 CD 与皮肤表现之间的每一种关联可能涉及的机制。异常的小肠通透性似乎与各种皮肤表现有关。然而,CD 与皮肤疾病之间的大多数关联都是基于病例报告和病例系列,以及一些对照研究。为了更好地评估皮肤区域在 CD 患者中的实际参与程度,需要进行大型多中心对照临床试验。