Wichmann I, Respaldiza N, Garcia-Lozano J R, Montes M, Sanchez-Roman J, Nuñez-Roldan A
Servicio de Inmunología, Hospital Universitario Virgen del Rocio, Servicio Andaluz de Salud, Sevilla, Spain.
Clin Exp Immunol. 2000 Mar;119(3):530-2. doi: 10.1046/j.1365-2249.2000.01154.x.
Autoantibodies against the transcriptional DEK protein have been considered characteristic of the pauciarticular onset subtype of juvenile rheumatoid arthritis (JRA) associated with iridocyclitis in young girls. In this study we investigated the presence of anti-DEK autoantibodies in the sera of 288 patients with SLE using a recombinant DEK protein as autoantigenic target. Thirty sera (10.4%) were positive against DEK protein by immunoblotting. Patients with anti-DEK autoantibodies show a lower frequency of cutaneous manifestation, exhibit more frequently certain markers of a chronic inflammatory status like anaemia and positivity for C-reactive protein, as well as a higher frequency of anti-double-stranded DNA autoantibodies. In contrast to JRA patients positive for anti-DEK autoantibodies, no association with erosive arthritis nor iridocyclitis were found in SLE. In conclusion, our results show that 10.4% of SLE patients from our area show antibodies against DEK protein, although this feature did not clearly establish a clinical subset of the disease.
针对转录DEK蛋白的自身抗体被认为是年轻女孩中与虹膜睫状体炎相关的少关节型幼年类风湿性关节炎（JRA）的特征。在本研究中，我们使用重组DEK蛋白作为自身抗原靶点，调查了288例系统性红斑狼疮（SLE）患者血清中抗DEK自身抗体的存在情况。通过免疫印迹法，30份血清（10.4%）对DEK蛋白呈阳性反应。抗DEK自身抗体阳性的患者皮肤表现频率较低，更频繁地出现某些慢性炎症状态的标志物，如贫血和C反应蛋白阳性，以及抗双链DNA自身抗体频率较高。与抗DEK自身抗体阳性的JRA患者不同，在SLE患者中未发现与侵蚀性关节炎或虹膜睫状体炎有关联。总之，我们的结果表明，我们地区10.4%的SLE患者显示出针对DEK蛋白的抗体，尽管这一特征并未明确界定该疾病的一个临床亚组。
