大肠杆菌的AcrD是一种氨基糖苷外排泵。
AcrD of Escherichia coli is an aminoglycoside efflux pump.
作者信息
Rosenberg E Y, Ma D, Nikaido H
机构信息
Departments of Molecular and Cell Biology, University of California, Berkeley, California 94720-3206, USA.
出版信息
J Bacteriol. 2000 Mar;182(6):1754-6. doi: 10.1128/JB.182.6.1754-1756.2000.
Abstract
AcrD, a transporter belonging to the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of [(3)H]dihydrostreptomycin and [(3)H]gentamicin than did the parent strain.
摘要
AcrD是一种属于耐药-固氮-细胞分裂家族的转运蛋白，已证明其参与氨基糖苷类药物的外排。acrD基因的缺失使阿米卡星、庆大霉素、新霉素、卡那霉素和妥布霉素的最低抑菌浓度降低了2至8倍，与亲本菌株相比，ΔacrD细胞积累了更高水平的[³H]双氢链霉素和[³H]庆大霉素。
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