卵磷脂分散体系中胆固醇分子运动和相分离的核磁共振描述
Nuclear magnetic resonance description of molecular motion and phase separations of cholesterol in lecithin dispersions.
作者信息
Opella S J, Yesinowski J P, Waugh J S
出版信息
Proc Natl Acad Sci U S A. 1976 Nov;73(11):3812-5. doi: 10.1073/pnas.73.11.3812.
Abstract
Proton-enhanced 13C nuclear magnetic resonance is used to obtain signals from labeled cholesterols in lecithin dispersions. The [26-(13)C]cholesterol resonance indicates that the aliphatic tail of the molecule undergoes reorientation fast enough to average completely the chemical shift anisotropy. In contrast, [4-(13)C]cholesterol signals are characteristic of limited anisotropic reorientation. The resonances from the 4 position are sensitive to the temperature-concentration phase diagram. A phase boundary is observed at about 20 mole percent cholesterol.
摘要
质子增强的13C核磁共振用于从卵磷脂分散体中的标记胆固醇获取信号。[26-(13)C]胆固醇共振表明分子的脂肪族尾部重新取向足够快，足以使化学位移各向异性完全平均化。相比之下，[4-(13)C]胆固醇信号具有有限各向异性重新取向的特征。来自4位的共振对温度-浓度相图敏感。在约20摩尔百分比的胆固醇处观察到一个相界。
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Nuclear magnetic resonance description of molecular motion and phase separations of cholesterol in lecithin dispersions.卵磷脂分散体系中胆固醇分子运动和相分离的核磁共振描述
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