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本文引用的文献

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Effect of membrane polyunsaturation on carrier-mediated transport in cultured retinoblastoma cells: alterations in taurine uptake.膜多不饱和脂肪酸对培养的视网膜母细胞瘤细胞中载体介导转运的影响：牛磺酸摄取的改变。
J Neurochem. 1984 Jan;42(1):254-61. doi: 10.1111/j.1471-4159.1984.tb09726.x.
2
The effect of cell damage on the density and steroidogenic capacity of rat testis Leydig cells, using an NADH exclusion test for determination of viability.利用NADH排除试验测定活力，研究细胞损伤对大鼠睾丸间质细胞密度和类固醇生成能力的影响。
J Steroid Biochem. 1983 Apr;18(4):411-4. doi: 10.1016/0022-4731(83)90059-6.
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Loss of EGF binding and cation transport response during differentiation of mouse neuroblastoma cells.小鼠神经母细胞瘤细胞分化过程中表皮生长因子结合及阳离子转运反应的丧失
J Cell Biochem. 1983;21(1):63-75. doi: 10.1002/jcb.240210108.
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The effects of iodine on the biological activities of myxoviruses.碘对黏液病毒生物学活性的影响。
J Hyg (Lond). 1980 Jun;84(3):381-8. doi: 10.1017/s0022172400026905.
5
Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.表皮生长因子对A431细胞的生长刺激作用：利用抗受体单克隆抗体鉴定表皮生长因子的高亲和力受体
Proc Natl Acad Sci U S A. 1983 Mar;80(5):1337-41. doi: 10.1073/pnas.80.5.1337.
6
Epidermal growth factor receptors and effect of epidermal growth factor on growth of human breast cancer cells in long-term tissue culture.表皮生长因子受体及表皮生长因子对长期组织培养中人类乳腺癌细胞生长的影响。
Cancer Res. 1982 Nov;42(11):4394-8.
7
Resolution of high and low affinity epidermal growth factor receptors. Inhibition of high affinity component by low temperature, cycloheximide, and phorbol esters.高亲和力和低亲和力表皮生长因子受体的解离。低温、环己酰亚胺和佛波酯对高亲和力组分的抑制作用。
J Biol Chem. 1982 Mar 25;257(6):3053-60.
8
Distinctive effects of hydrocortisone on the modulation of EGF binding and cell growth in HeLa cells grown in defined medium.氢化可的松对在限定培养基中生长的HeLa细胞表皮生长因子（EGF）结合及细胞生长调节的独特作用。
J Cell Physiol. 1981 Jul;108(1):83-90. doi: 10.1002/jcp.1041080111.
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Effect of the membrane lipid environment on the properties of insulin receptors.膜脂质环境对胰岛素受体特性的影响。
Diabetes. 1981 Sep;30(9):773-80. doi: 10.2337/diab.30.9.773.
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Utilization of fatty acid supplements by cultured animal cells.培养的动物细胞对脂肪酸补充剂的利用。
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脂肪酸对人宫颈癌细胞和子宫内膜癌细胞生长的控制

Fatty acid control of growth of human cervical and endometrial cancer cells.

作者信息

Gleeson R P, Ayub M, Wright J T, Wood C B, Habib N A, Soutter W P, Sullivan M H, White J O

机构信息

Institute of Obstetrics and Gynaecology, Hammersmith Hospital, London, UK.

出版信息

Br J Cancer. 1990 Apr;61(4):500-3. doi: 10.1038/bjc.1990.113.

DOI:10.1038/bjc.1990.113
PMID:2331435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1971358/
Abstract

Stearic acid and iodo-stearic and inhibited cell growth in a cervical cancer cell line (HOG-1) in a dose-related manner, with a half maximal effect at 50 microM stearic acid. Addition of oleic acid abrogated the effect of stearic acid. EGF-stimulated DNA synthesis and growth of HOG-1 cells was inhibited in the presence of stearic acid without any apparent effect on EGF receptor number or affinity.

摘要

硬脂酸和碘代硬脂酸以剂量相关的方式抑制一种宫颈癌细胞系（HOG-1）的细胞生长，在50微摩尔硬脂酸时达到半数最大效应。添加油酸可消除硬脂酸的作用。在存在硬脂酸的情况下，表皮生长因子（EGF）刺激的HOG-1细胞的DNA合成和生长受到抑制，而对EGF受体数量或亲和力没有任何明显影响。