脂肪酸对人宫颈癌细胞和子宫内膜癌细胞生长的控制
Fatty acid control of growth of human cervical and endometrial cancer cells.
作者信息
Gleeson R P, Ayub M, Wright J T, Wood C B, Habib N A, Soutter W P, Sullivan M H, White J O
机构信息
Institute of Obstetrics and Gynaecology, Hammersmith Hospital, London, UK.
出版信息
Br J Cancer. 1990 Apr;61(4):500-3. doi: 10.1038/bjc.1990.113.
Abstract
Stearic acid and iodo-stearic and inhibited cell growth in a cervical cancer cell line (HOG-1) in a dose-related manner, with a half maximal effect at 50 microM stearic acid. Addition of oleic acid abrogated the effect of stearic acid. EGF-stimulated DNA synthesis and growth of HOG-1 cells was inhibited in the presence of stearic acid without any apparent effect on EGF receptor number or affinity.
摘要
硬脂酸和碘代硬脂酸以剂量相关的方式抑制一种宫颈癌细胞系（HOG-1）的细胞生长，在50微摩尔硬脂酸时达到半数最大效应。添加油酸可消除硬脂酸的作用。在存在硬脂酸的情况下，表皮生长因子（EGF）刺激的HOG-1细胞的DNA合成和生长受到抑制，而对EGF受体数量或亲和力没有任何明显影响。
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