Kim H S, Chun Y S, Hann S K, Park W H
Department of Dermatology, College of Medicine Pochon CHA University, Seoul, Korea.
J Dermatol. 2000 Jan;27(1):31-4. doi: 10.1111/j.1346-8138.2000.tb02114.x.
We report a case of a 28-year-old woman with myasthenia gravis who developed linear scleroderma seven years later. Myasthenia gravis and scleroderma are rarely found in direct association with each other; there are only five such reported cases, all of which were systemic scleroderma patients. Although localized and systemic scleroderma are distinct entities, autoimmunity is believed to be involved in the pathogenesis of both. Myasthenia gravis and scleroderma may occur coincidentally, but an autoimmune predisposition seems to be the more likely underlying cause, as evidenced by an increased incidence of autoantibodies and autoimmune diseases.
我们报告了一例28岁重症肌无力女性患者，7年后出现了线状硬皮病。重症肌无力和硬皮病很少直接相关；仅有5例此类报告病例，均为系统性硬皮病患者。尽管局限性和系统性硬皮病是不同的疾病，但自身免疫被认为参与了两者的发病机制。重症肌无力和硬皮病可能同时发生，但自身免疫易感性似乎更可能是潜在原因，自身抗体和自身免疫性疾病发病率增加证明了这一点。
