局限性硬皮病中的抗半乳糖基免疫球蛋白G抗体
Anti-agalactosyl immunoglobulin G antibodies in localized scleroderma.
作者信息
Mimra Yoshihiro, Ihn Hronobu, Jinnin Masatoshi, Asano Yoshihide, Yamane Kenichi, Yazawa Norihito, Tamaki Kunihiko
机构信息
Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
出版信息
Int J Dermatol. 2005 Oct;44(10):817-20. doi: 10.1111/j.1365-4632.2005.02584.x.
BACKGROUND
Anti-agalactosyl immunoglobulin G (IgG) antibodies (anti-AG IgG) have been reported to be detected and correlated with disease activity in some collagen diseases.
METHOD
Forty-seven serum samples from patients with localized scleroderma were examined using an enzyme-linked immunosorbent assay.
RESULTS
Anti-AG IgG were positive in 19% of patients with localized scleroderma. The frequency of anti-AG IgG in generalized morphea was much higher than that in linear scleroderma or that in morphea. There was a significant correlation between anti-AG IgG levels and the number of the sclerotic lesions and between anti-AG IgG levels and the number of involved areas. The levels of anti-AG IgG were significantly higher in patients with antinuclear antibody, antisingle-stranded DNA antibody or rheumatoid factor than in those without.
CONCLUSION
Anti-AG IgG can be an indicator of the severity of localized scleroderma.
背景
据报道，在一些胶原病中可检测到抗半乳糖基免疫球蛋白G（IgG）抗体（抗AG IgG），且其与疾病活动相关。
方法
采用酶联免疫吸附测定法检测47例局限性硬皮病患者的血清样本。
结果
19%的局限性硬皮病患者抗AG IgG呈阳性。泛发性硬斑病中抗AG IgG的频率远高于线状硬皮病或硬斑病中的频率。抗AG IgG水平与硬化性病变数量以及与受累区域数量之间存在显著相关性。抗核抗体、抗单链DNA抗体或类风湿因子阳性的患者抗AG IgG水平显著高于无这些抗体的患者。
结论
抗AG IgG可作为局限性硬皮病严重程度的一个指标。
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