Thiboutot D
Section of Dermatology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033, USA.
Arch Fam Med. 2000 Feb;9(2):179-87. doi: 10.1001/archfami.9.2.179.
Successful management of acne requires careful patient evaluation followed by consideration of several patient and medication factors when selecting a particular therapeutic regimen. Within the last few years, several new agents for the treatment of acne have become available that afford greater flexibility in the treatment of this prevalent dermatologic disorder. These include adapalene, tazarotene, 2 new topical tretinoin formulations, azelaic acid, a new sodium sulfacetamide formulation, and an oral contraceptive recently approved by the Food and Drug Administration for the treatment of acne. After a brief overview of the pathophysiology of acne and existing therapies, this review evaluates the new antiacne agents and how they can be integrated into a successful treatment strategy that takes into account acne severity and predominant lesion type as well as age, skin type, lifestyle, motivation, and the presence of coexisting conditions.
成功治疗痤疮需要对患者进行仔细评估，然后在选择特定治疗方案时考虑多个患者因素和药物因素。在过去几年中，有几种治疗痤疮的新药可供使用，这为治疗这种常见的皮肤病提供了更大的灵活性。这些药物包括阿达帕林、他扎罗汀、两种新的外用维甲酸制剂、壬二酸、一种新的磺胺醋酰钠制剂，以及最近美国食品药品监督管理局批准用于治疗痤疮的口服避孕药。在简要概述痤疮的病理生理学和现有治疗方法之后，本综述评估了这些新的抗痤疮药物，以及如何将它们纳入一个成功的治疗策略中，该策略要考虑痤疮的严重程度、主要皮损类型以及年龄、皮肤类型、生活方式、治疗积极性和并存疾病等因素。
