Khan Barkat Ali, Akhtar Naveed
Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. Head of Department: Prof. Dr. Naveed Akhtar.
Postepy Dermatol Alergol. 2014 Aug;31(4):229-34. doi: 10.5114/pdia.2014.40934. Epub 2014 Sep 8.
Numerous plant products described in the scientific literature show distinct activities on the skin, such as moisturizing, antioxidant, sunscreen, anti-acne and depigmentation.
The main objective of this study was to compare the effectiveness of emulsion formulations containing plant extracts (Hippophae rhamnoides and Cassia fistula) and placebo (without plant extracts) on acne patients.
A single-blind, randomized, placebo-controlled, split-face study was designed. Two groups of 25 patients each (aged 18-37 years) with grade I and grade II acne vulgaris received active formulations on the left side of their cheeks and placebo on the right side of their cheeks twice daily for 12 weeks. Prior to the study, signed consent was obtained from each patient. The anti-bacterial activity of the extracts and formulations was tested in vitro. The skin sebum contents of patients were evaluated by the sebumeter(®) and subjectively using a clinical evaluation before and after treatment of 12 weeks. One way ANOVA and Kruskal-Wallis tests were used in the statistical analysis.
A significant (p ≤ 0.05) decrease in the level of sebum contents was observed in both groups who used formulations (F1 and F2) containing the plant extract. The difference between pre- and post-treatment levels of sebum contents was statistically significant (p ≤ 0.05). Formulations containing plant extracts were found effective in the reduction of skin sebum contents (anti-acne effects) sebumetrically as well as clinically when compared to placebo (F3).
Formulations with 5% plant extracts could be effective, safe, and well-tolerated topical medications for grade I and grade II acne vulgaris.
科学文献中描述的众多植物产品对皮肤表现出不同的活性，如保湿、抗氧化、防晒、抗痤疮和色素沉着。
本研究的主要目的是比较含植物提取物（沙棘和决明子）的乳液配方与安慰剂（不含植物提取物）对痤疮患者的疗效。
设计了一项单盲、随机、安慰剂对照、双侧面部研究。两组各25名患者（年龄18 - 37岁），患有I级和II级寻常痤疮，每天两次在脸颊左侧使用活性配方，右侧使用安慰剂，持续12周。研究前，获得了每位患者的签署同意书。体外测试了提取物和配方的抗菌活性。在治疗12周前后，使用皮脂测定仪（®）并通过临床评估主观地评估患者的皮肤皮脂含量。统计分析采用单因素方差分析和克鲁斯卡尔 - 沃利斯检验。
在使用含植物提取物配方（F1和F2）的两组中，皮脂含量水平均显著（p≤0.05）下降。治疗前后皮脂含量水平的差异具有统计学意义（p≤0.05）。与安慰剂（F3）相比，含植物提取物的配方在皮脂测定以及临床方面均被发现对降低皮肤皮脂含量（抗痤疮作用）有效。
含5%植物提取物的配方对于I级和II级寻常痤疮可能是有效、安全且耐受性良好的局部用药。
