Gonzalez-Gay Miguel A, Garcia-Porrua Carlos, Guerrero Jose, Rodriguez-Ledo Pilar, Llorca Javier
Hospital Xeral-Calde, Lugo, Spain.
Arthritis Rheum. 2003 Jun 15;49(3):388-93. doi: 10.1002/art.11115.
To assess the epidemiology of the primary systemic vasculitides (PSV) in a well-defined population of southern Europe over a 14-year period using the Chapel Hill Consensus Conference (CHCC) definitions.
The case records of all patients 15 years or older with vasculitis diagnosed between January 1988 and December 2001 at a single reference hospital in the Lugo region of northwest Spain were reviewed. Incidence rates were age- and sex-adjusted to the European standard population. Patients were classified as having PSV according to the CHCC definitions.
Fifty-four Lugo residents (29 men) fulfilled the CHCC definitions for PSV. The mean age was 60.7 +/- 13.5 years (men: 61.0 +/- 13.4; women: 60.4 +/- 13.8 years). The overall annual incidence of PSV was 13.07/million (95% confidence interval [95% CI] 8.89-19.22). PSV were slightly more common in men. The age-specific incidence showed a clear increase with age. A peak in the 55-64 year age group for the whole group of patients with PSV was observed (34.9/million; 95% CI 28.6-42.6). Nonrandom periodical peaks of incidence every 3 years were only observed when the group of PSV was considered as a whole (P = 0.040). The annual incidence was 2.95/million (95% CI 1.44-6.05) for Wegener's granulomatosis (WG) and 7.91/million (95% CI 4.74-13.20) for microscopic polyangiitis (MPA) (P = 0.035). None of the patients with Churg Strauss syndrome (n = 4) lived in a rural area.
Our observations support an increasing incidence of PSV with age. In patients from northwest Spain defined by the CHCC definitions, MPA is more common than WG.
采用查珀尔希尔共识会议（CHCC）定义，评估14年间南欧一个明确界定人群中原发性系统性血管炎（PSV）的流行病学情况。
回顾了1988年1月至2001年12月期间在西班牙西北部卢戈地区一家参考医院确诊为血管炎的所有15岁及以上患者的病历。发病率按年龄和性别调整至欧洲标准人群。根据CHCC定义将患者分类为患有PSV。
54名卢戈居民（29名男性）符合PSV的CHCC定义。平均年龄为60.7±13.5岁（男性：61.0±13.4岁；女性：60.4±13.8岁）。PSV的总体年发病率为13.07/百万（95%置信区间[95%CI]8.89 - 19.22）。PSV在男性中略为常见。年龄特异性发病率随年龄明显增加。在整个PSV患者组中，观察到55 - 64岁年龄组出现发病高峰（34.9/百万；95%CI 28.6 - 42.6）。仅在将PSV组作为一个整体考虑时，观察到每3年出现一次非随机的发病高峰（P = 0.040）。韦格纳肉芽肿（WG）的年发病率为2.95/百万（95%CI 1.44 - 6.05），显微镜下多血管炎（MPA）的年发病率为7.91/百万（95%CI 4.74 - 13.20）（P = 0.035）。4例变应性肉芽肿性血管炎（Churg Strauss syndrome）患者均不住在农村地区。
我们的观察结果支持PSV发病率随年龄增加。在根据CHCC定义确定的西班牙西北部患者中，MPA比WG更常见。
