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Clusterin is a secreted mammalian chaperone.

作者信息

Wilson M R, Easterbrook-Smith S B

机构信息

Dept of Biological Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW Australia 2522.

出版信息

Trends Biochem Sci. 2000 Mar;25(3):95-8. doi: 10.1016/s0968-0004(99)01534-0.

DOI:10.1016/s0968-0004(99)01534-0
PMID:10694874
Abstract
摘要

相似文献

1
Clusterin is a secreted mammalian chaperone.
Trends Biochem Sci. 2000 Mar;25(3):95-8. doi: 10.1016/s0968-0004(99)01534-0.
2
Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state.
Biochemistry. 2000 Dec 26;39(51):15953-60. doi: 10.1021/bi002189x.
3
Small heat-shock proteins and clusterin: intra- and extracellular molecular chaperones with a common mechanism of action and function?小分子热休克蛋白与簇集素:具有共同作用机制和功能的细胞内和细胞外分子伴侣?
IUBMB Life. 2003 Dec;55(12):661-8. doi: 10.1080/15216540310001640498.
4
Binding of human clusterin by Staphylococcus epidermidis.
FEMS Immunol Med Microbiol. 2001 Oct;31(3):197-202. doi: 10.1111/j.1574-695X.2001.tb00520.x.
5
Up-regulation of clusterin (apolipoprotein J) and apolipoprotein E in cultured rat spinal cord neurones.培养的大鼠脊髓神经元中簇集蛋白(载脂蛋白J)和载脂蛋白E的上调。
Schweiz Arch Neurol Psychiatr (1985). 1994;145(3):20-1.
6
Evidence that clusterin has discrete chaperone and ligand binding sites.簇集素具有离散的伴侣蛋白结合位点和配体结合位点的证据。
Biochemistry. 2002 Jan 8;41(1):282-91. doi: 10.1021/bi0157666.
7
The thousand doors that lead to death: p53-dependent repression and apoptosis.通向死亡的千扇门:p53 依赖的抑制与凋亡
Cancer Biol Ther. 2003 Jul-Aug;2(4):381-2. doi: 10.4161/cbt.2.4.439.
8
Clusterin has chaperone-like activity similar to that of small heat shock proteins.簇集素具有类似于小分子热休克蛋白的伴侣样活性。
J Biol Chem. 1999 Mar 12;274(11):6875-81. doi: 10.1074/jbc.274.11.6875.
9
Clusterin: physiologic and pathophysiologic considerations.簇集素:生理与病理生理方面的考量
Int J Biochem Cell Biol. 1995 Jul;27(7):633-45. doi: 10.1016/1357-2725(95)00027-m.
10
Intracellular clusterin induces G2-M phase arrest and cell death in PC-3 prostate cancer cells1.细胞内簇集素诱导PC-3前列腺癌细胞的G2-M期阻滞和细胞死亡1。
Cancer Res. 2004 Sep 1;64(17):6174-82. doi: 10.1158/0008-5472.CAN-04-0920.

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Elucidating the function of clusterin in the progression of diabetic kidney disease.阐明簇集素在糖尿病肾病进展中的作用。
Front Pharmacol. 2025 May 14;16:1573654. doi: 10.3389/fphar.2025.1573654. eCollection 2025.
2
Cardioprotective effects of the extracellular chaperone clusterin in acute myocardial infarction.细胞外伴侣蛋白簇集素在急性心肌梗死中的心脏保护作用。
Eur J Clin Invest. 2025 Oct;55(10):e70076. doi: 10.1111/eci.70076. Epub 2025 May 26.
3
TNF-α-Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells.
肿瘤坏死因子-α驱动的极化表皮生长因子受体转运变化促进了来自MDCK上皮细胞顶端表面的磷脂酰肌醇3-激酶/蛋白激酶B信号传导。
Traffic. 2025 Apr-Jun;26(4-6):e70005. doi: 10.1111/tra.70005.
4
CLU alleviates Alzheimer's disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density.CLU通过调节星形胶质细胞反应性和小胶质细胞依赖性突触密度来减轻与阿尔茨海默病相关的进程。
Neuron. 2025 Jun 18;113(12):1925-1946.e11. doi: 10.1016/j.neuron.2025.03.034. Epub 2025 Apr 30.
5
Assessing Bovine Male Fertility in a Technological Age.在技术时代评估公牛的生育能力。
Adv Anat Embryol Cell Biol. 2025;240:297-329. doi: 10.1007/978-3-031-70126-9_7.
6
Evaluation of tear and serum clusterin levels in thyroid ophthalmopathy patients.甲状腺眼病患者泪液和血清簇集素水平的评估。
Int Ophthalmol. 2025 Mar 22;45(1):117. doi: 10.1007/s10792-025-03501-w.
7
The secreted host-cell protein clusterin interacts with PmpD and promotes infection.分泌型宿主细胞蛋白簇集素与PmpD相互作用并促进感染。
Front Cell Infect Microbiol. 2025 Jan 27;14:1519883. doi: 10.3389/fcimb.2024.1519883. eCollection 2024.
8
Clusterin: a double-edged sword in cancer and neurological disorders.聚集素:癌症和神经疾病中的一把双刃剑。
EXCLI J. 2024 Jul 9;23:912-936. doi: 10.17179/excli2024-7369. eCollection 2024.
9
Astrocyte-derived clusterin disrupts glial physiology to obstruct remyelination in mouse models of demyelinating diseases.星形胶质细胞衍生的聚集素破坏神经胶质生理学,阻碍脱髓鞘疾病小鼠模型中的髓鞘再生。
Nat Commun. 2024 Sep 6;15(1):7791. doi: 10.1038/s41467-024-52142-7.
10
Protective effect of clusterin against interleukin-1β-induced apoptosis and inflammation in human knee osteoarthritis chondrocytes.簇集蛋白对人膝骨关节炎软骨细胞白细胞介素-1β诱导的凋亡和炎症的保护作用。
Clin Transl Sci. 2024 Jul;17(7):e13881. doi: 10.1111/cts.13881.