小GTP酶与钙黏蛋白依赖性细胞间黏附的调控
Small GTPases and regulation of cadherin dependent cell-cell adhesion.
作者信息
Braga V M
机构信息
MRC Laboratory for Molecular Cell Biology, University College London, UK.
出版信息
Mol Pathol. 1999 Aug;52(4):197-202. doi: 10.1136/mp.52.4.197.
Abstract
Cadherins belong to a superfamily of cell-cell adhesion receptors that bind to the same type of molecules (homotypic interaction) in a calcium dependent manner. Different members of the family are found in a wide variety of cell types and cadherin adhesive function plays a role in cell fate, segregation, and differentiation, which ensures the higher order of organisation found in many tissues. This review will focus on the role that cadherin adhesiveness plays in the differentiation of epithelial cells, and how cadherin function can be regulated by proteins of the small GTPase family. In the text, readers are referred to recent reviews and other chapters covering important topics that are not discussed here because of space limitation.
摘要
钙黏蛋白属于细胞间黏附受体超家族，它们以钙依赖的方式与同种类型分子（同型相互作用）结合。该家族的不同成员存在于多种细胞类型中，钙黏蛋白的黏附功能在细胞命运、分离和分化中发挥作用，这确保了许多组织中存在的更高层次的组织结构。本综述将重点关注钙黏蛋白黏附性在上皮细胞分化中的作用，以及小GTPase家族蛋白如何调节钙黏蛋白的功能。由于篇幅限制，文中会引用近期的综述以及其他章节中涉及未在此讨论的重要主题的内容。
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本文引用的文献
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