小GTP酶与钙黏蛋白依赖性细胞间黏附的调控
Small GTPases and regulation of cadherin dependent cell-cell adhesion.
作者信息
Braga V M
机构信息
MRC Laboratory for Molecular Cell Biology, University College London, UK.
出版信息
Mol Pathol. 1999 Aug;52(4):197-202. doi: 10.1136/mp.52.4.197.
Abstract
Cadherins belong to a superfamily of cell-cell adhesion receptors that bind to the same type of molecules (homotypic interaction) in a calcium dependent manner. Different members of the family are found in a wide variety of cell types and cadherin adhesive function plays a role in cell fate, segregation, and differentiation, which ensures the higher order of organisation found in many tissues. This review will focus on the role that cadherin adhesiveness plays in the differentiation of epithelial cells, and how cadherin function can be regulated by proteins of the small GTPase family. In the text, readers are referred to recent reviews and other chapters covering important topics that are not discussed here because of space limitation.
摘要
钙黏蛋白属于细胞间黏附受体超家族，它们以钙依赖的方式与同种类型分子（同型相互作用）结合。该家族的不同成员存在于多种细胞类型中，钙黏蛋白的黏附功能在细胞命运、分离和分化中发挥作用，这确保了许多组织中存在的更高层次的组织结构。本综述将重点关注钙黏蛋白黏附性在上皮细胞分化中的作用，以及小GTPase家族蛋白如何调节钙黏蛋白的功能。由于篇幅限制，文中会引用近期的综述以及其他章节中涉及未在此讨论的重要主题的内容。
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本文引用的文献
1
The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene.
Trends Biochem Sci. 1999 Feb;24(2):73-6. doi: 10.1016/s0968-0004(98)01343-7.
2
p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry.
Oncogene. 1999 Jan 28;18(4):869-76. doi: 10.1038/sj.onc.1202396.
3
Regulation of cadherin function by Rho and Rac: modulation by junction maturation and cellular context.
Mol Biol Cell. 1999 Jan;10(1):9-22. doi: 10.1091/mbc.10.1.9.
4
Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase.
J Cell Biol. 1998 Nov 30;143(5):1385-98. doi: 10.1083/jcb.143.5.1385.
5
Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation.
J Cell Biol. 1998 Aug 10;142(3):837-46. doi: 10.1083/jcb.142.3.837.
6
Rho GTPases.
J Biol Chem. 1998 Aug 14;273(33):20685-8. doi: 10.1074/jbc.273.33.20685.
7
Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion.
Science. 1998 Aug 7;281(5378):832-5. doi: 10.1126/science.281.5378.832.
8
Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly.
Mol Biol Cell. 1998 Aug;9(8):2185-200. doi: 10.1091/mbc.9.8.2185.
9
E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1).
J Cell Biol. 1998 Jul 27;142(2):557-71. doi: 10.1083/jcb.142.2.557.
10
Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering.
Oncogene. 1998 Jul 9;17(1):57-65. doi: 10.1038/sj.onc.1201905.
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