Kohno J, Asai Y, Nishio M, Sakurai M, Kawano K, Hiramatsu H, Kameda N, Kishi N, Okuda T, Komatsubara S
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., Toda-shi, Saitama, Japan.
J Antibiot (Tokyo). 1999 Dec;52(12):1114-23. doi: 10.7164/antibiotics.52.1114.
Four new antibiotics, TMC-171A (2), B (3), C (4) and TMC-154 (5) have been isolated from the fermentation of fungal strains Gliocladium sp. TC 1304 and TC 1282, respectively. Spectroscopic and degradation studies have shown that TMC-171s and TMC-154 were new members of the TMC-151 class of antibiotics, unique polyketides modified with a D-mannose and a D-mannitol or a D-arabitol. These compounds showed moderate cytotoxicity to various tumor cell lines.
分别从真菌菌株Gliocladium sp. TC 1304和TC 1282的发酵产物中分离出了四种新型抗生素，即TMC-171A（2）、B（3）、C（4）和TMC-154（5）。光谱和降解研究表明，TMC-171s和TMC-154是TMC-151类抗生素的新成员，是经D-甘露糖和D-甘露糖醇或D-阿拉伯糖醇修饰的独特聚酮化合物。这些化合物对多种肿瘤细胞系显示出中等程度的细胞毒性。
