TMC - 171A、B、C以及TMC - 154，是由粘帚霉属菌株TC 1304和TC 1282产生的新型聚酮类抗生素。
TMC-171A,B,C and TMC-154, novel polyketide antibiotics produced by Gliocladium sp. TC 1304 and TC 1282.
作者信息
Kohno J, Asai Y, Nishio M, Sakurai M, Kawano K, Hiramatsu H, Kameda N, Kishi N, Okuda T, Komatsubara S
机构信息
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., Toda-shi, Saitama, Japan.
出版信息
J Antibiot (Tokyo). 1999 Dec;52(12):1114-23. doi: 10.7164/antibiotics.52.1114.
Four new antibiotics, TMC-171A (2), B (3), C (4) and TMC-154 (5) have been isolated from the fermentation of fungal strains Gliocladium sp. TC 1304 and TC 1282, respectively. Spectroscopic and degradation studies have shown that TMC-171s and TMC-154 were new members of the TMC-151 class of antibiotics, unique polyketides modified with a D-mannose and a D-mannitol or a D-arabitol. These compounds showed moderate cytotoxicity to various tumor cell lines.
分别从真菌菌株Gliocladium sp. TC 1304和TC 1282的发酵产物中分离出了四种新型抗生素，即TMC-171A（2）、B（3）、C（4）和TMC-154（5）。光谱和降解研究表明，TMC-171s和TMC-154是TMC-151类抗生素的新成员，是经D-甘露糖和D-甘露糖醇或D-阿拉伯糖醇修饰的独特聚酮化合物。这些化合物对多种肿瘤细胞系显示出中等程度的细胞毒性。
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