Kankonkar R C, Kulkurni D G, Hulikavi C B
Anti Scorpion-Venom-Serum Project, Haffkine Biopharmaceutical Corporation Limited, Mumbai.
J Postgrad Med. 1998 Oct-Dec;44(4):85-92.
A number of children and adults, especially pregnant women succumb to the sting by red Scorpion (Buthus tamalus) in Konkan region--particularly on the coastal line. No specific antiserum or any other antidote is available to treat a victim of scorpion bite and hence the need to prepare a potent antiserum. Red Scorpion (B. tamalus) venom is a mixture of a number of protein moieties and neurotoxins of low molecular weight. Therefore, the venom is poor in antigenic composition and it is difficult to get antibodies specific to neutralise lethal factor/factors. Using Bentonite as an adjuvant and extending the period of immunization a potent antiserum has been prepared capable of neutralising the lethal factor/factors. In vivo testing carried out in albino mice, guinea pigs, dogs and langurs confirms this finding and shows that the antiserum is quite effective in neutralising the scorpion venom to save the life of envenomated animals.
在孔卡恩地区，尤其是沿海地带，许多儿童和成年人，特别是孕妇会死于红蝎子（Buthus tamalus）的蜇伤。目前没有特效抗血清或其他解毒剂来治疗蝎子蜇伤的受害者，因此需要制备一种有效的抗血清。红蝎子（B. tamalus）毒液是多种蛋白质成分和低分子量神经毒素的混合物。因此，毒液的抗原成分较差，很难获得能中和致死因子的特异性抗体。通过使用膨润土作为佐剂并延长免疫时间，制备出了一种能够中和致死因子的有效抗血清。在白化小鼠、豚鼠、狗和叶猴身上进行的体内试验证实了这一发现，并表明该抗血清在中和蝎子毒液以挽救中毒动物生命方面相当有效。
