Tze W J, Wong F C, Chen L M
Diabetologia. 1979 Apr;16(4):247-52. doi: 10.1007/BF01221951.
Implantable artificial capillary units containing approximately 1,200 allogeneic rat islets, or approximately 3,000 xenogeneic rabbit or human islets as an implantable artificial endocrine pancreas (IAEP) were implanted in streptozotocin-induced (55 mg/kg) diabetic rats. A total of 26 rats received IAEP containing allogeneic islets. Twenty were short term experiments which lasted for 12-24 h. Four recipients survived between 1-3 days and the remaining two for 4 and 11 days respectively. Five diabetic rats received IAEP containing xenogeneic islets. The four recipients of IAEP containing rabbit islets survived up to 4 days while the recipient of IAEP containing human islets survived for 8 days. Following implantation, a decrease of plasma glucose from the initial value of 500 mg/dl to normoglycaemia and a corresponding increase in circulating levels of insulin up to 100 muU/ml were observed in the recipient animals. Furthermore the IAEPs were shown to produce a near normal plasma glucose and insulin response to an intravenous glucose tolerance test. These findings suggest the feasibility of achieving amelioration of diabetes with allogeneic or xenogeneic pancreatic islets implanted as an artificial endocrine pancreas unit in the experimental animals which has the potential of future clinical application in man.
将含有约1200个同种异体大鼠胰岛，或约3000个异种兔或人胰岛的可植入式人工毛细血管单元作为可植入式人工内分泌胰腺（IAEP）植入链脲佐菌素诱导（55mg/kg）的糖尿病大鼠体内。共有26只大鼠接受了含同种异体胰岛的IAEP。其中20只进行短期实验，持续12 - 24小时。4只受体存活1 - 3天，其余两只分别存活4天和11天。5只糖尿病大鼠接受了含异种胰岛的IAEP。接受含兔胰岛IAEP的4只受体存活长达4天，而接受含人胰岛IAEP的受体存活了8天。植入后，受体动物的血浆葡萄糖从初始值500mg/dl降至正常血糖水平，循环胰岛素水平相应升高至100μU/ml。此外，IAEP在静脉葡萄糖耐量试验中表现出接近正常的血浆葡萄糖和胰岛素反应。这些发现表明，将同种异体或异种胰岛作为人工内分泌胰腺单元植入实验动物体内来改善糖尿病具有可行性，这在未来有可能应用于人类临床。
