Hennequin C, Kauffmann-Lacroix C, Jobert A, Viard J P, Ricour C, Jacquemin J L, Berche P
Service de Microbiologie, Hôpital Necker-Enfants Malades, Paris, France.
Eur J Clin Microbiol Infect Dis. 2000 Jan;19(1):16-20. doi: 10.1007/s100960050003.
Four cases of Saccharomyces boulardii fungemia, a very rare side effect of Saccharomyces boulardii therapy, are reported. The clinical impact of Saccharomyces boulardii infection appeared to be moderate. However, even though organ involvement was never demonstrated, septic shock with no other etiology was observed in one of our patients. All patients had an indwelling vascular catheter. Contamination of the air, environmental surfaces, and hands following the opening of a packet suggests that catheter contamination may have been a source of infection. To prevent catheter contamination it is recommended that packets or capsules of Saccharomyces boulardii be opened with gloves, outside the patient's room.
据报道，有4例发生了布拉氏酵母菌菌血症，这是布拉氏酵母菌治疗非常罕见的副作用。布拉氏酵母菌感染的临床影响似乎较为温和。然而，尽管从未证实有器官受累，但我们的一名患者出现了无其他病因的感染性休克。所有患者均有留置血管导管。打开包装后空气、环境表面和手部受到污染，提示导管污染可能是感染源。为防止导管污染，建议戴手套在患者病房外打开布拉氏酵母菌的包装或胶囊。
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