布拉酵母菌益生菌相关真菌血症：质疑这种预防性益生菌使用的安全性。
Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use.
作者信息
Martin Isabella W, Tonner Rita, Trivedi Julie, Miller Heather, Lee Richard, Liang Xinglun, Rotello Leo, Isenbergh Elena, Anderson Jennifer, Perl Trish, Zhang Sean X
机构信息
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hospital Epidemiology and Infection Control, Suburban Hospital, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
出版信息
Diagn Microbiol Infect Dis. 2017 Mar;87(3):286-288. doi: 10.1016/j.diagmicrobio.2016.12.004. Epub 2016 Dec 16.
We report a case of fungemia in an immunocompetent patient after administration of probiotic containing Saccharomyces boulardii. We demonstrated the strain relatedness of the yeast from the probiotic capsule and the yeast causing fungal infection using genomic and proteomic typing methods. Our study questions the safety of this preventative biotherapy.
我们报告了一例免疫功能正常的患者在服用含布拉酵母菌的益生菌后发生真菌血症的病例。我们使用基因组和蛋白质组分型方法证明了益生菌胶囊中的酵母菌与引起真菌感染的酵母菌之间的菌株相关性。我们的研究对这种预防性生物疗法的安全性提出了质疑。
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