Unique Properties of Yeast Probiotic Saccharomyces boulardii CNCM I-745: A Narrative Review.

Probiotics, both bacterial and yeast, have long been associated with a beneficial health history and human well-being. Among yeasts, is a genus that is efficacious in rendering better human health, with () CNCM I-745 being classified as a probiotic agent. The present review highlights the unique properties of and its rolein the prevention of antibiotic-associated diarrhea (AAD) and pediatric acute gastroenteritis (PAGE) in comparison to bacterial probiotics. Its unique properties,such as viability over a wide pH range, inability to acquire antibiotic resistance genes, and property to achieve a steady state rapidly, have given an edge over bacterial probiotics. In AAD patients, prophylactic use of has shown a significantly lower risk of AAD (in comparison to controls) and restored the diversity of gut microbiota. Among Indian children with PAGE, CNCM I-745 was found superior to GG and four strains of in shortening the duration of diarrhea and reducing the length of hospital stay. CNCM I-745 being considered a safe probiotic for use in children and adults also finds recommendations in several international guidelines for the management of acute diarrhea. The current review discusses evidence for the proven efficacy and safety of CNCM I-745 as a probiotic for preventing gastrointestinal disorders.