Glaser L, Loewy A
J Biol Chem. 1979 Apr 10;254(7):2184-6.
Bacillus subtilis W-23, when placed in phosphate-free medium, ceases to synthesize teichoic acid and synthesizes teichuronic acid. The enzymatic basis for the cessation of teichoic acid synthesis is the irreversible inhibition of the first membrane-bound enzyme involved in teichoic acid synthesis which catalyzes the reaction Undecapenol-P + UDP-GlcNAc leads to undecaprenol-P-P-GlcNAc + UMP.
枯草芽孢杆菌W-23置于无磷酸盐培养基中时,会停止合成磷壁酸并转而合成磷酰壁酸。磷壁酸合成停止的酶学基础是参与磷壁酸合成的第一种膜结合酶被不可逆抑制,该酶催化反应:十一异戊烯醇磷酸 + UDP-葡萄糖胺生成十一异戊烯醇二磷酸葡萄糖胺 + 尿苷一磷酸。