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H-2相关的细胞毒性T细胞对甲病毒感染反应性的调控。在分化和刺激过程中H-2Dk的存在将低反应基因型的干细胞转化为反应表型的T细胞。

H-2-linked control of cytotoxic T-cell responsiveness to alphavirus infection. Presence of H-2Dk during differentiation and stimulation converts stem cells of low responder genotype to T cells of responder phenotype.

作者信息

Mullbacher A, Blanden R V

出版信息

J Exp Med. 1979 Mar 1;149(3):786-90. doi: 10.1084/jem.149.3.786.

DOI:10.1084/jem.149.3.786
PMID:107264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2184822/
Abstract

Secondary Tc cells generated against Sindbis virus (SIN) are restricted to Dk. All other H-2K or D regions tested show low specific responsiveness. F1 hybrids between low and high responders show dominance of responsiveness but lack complementation. When BALB/c (KdIdDd) low responder fetal liver stem cells were allowed to mature in irradiated high responder recipients C3H.OH (KdIdDk) a response to Dk plus SIN could be generated with Tc cells of BALB/c origin. This result, together with the failure of complementation in the F1 hybrids, implies that the lesion of low responsiveness is in the inability of viral antigen to stimulate a Tc-cell response in association with any self H-2K or H-2D molecule (of those tested) other than H-2Dk. Hypotheses compatible with these data are discussed.

摘要

针对辛德毕斯病毒（SIN）产生的二级Tc细胞受限于Dk。所测试的所有其他H-2K或D区域显示出低特异性反应性。低反应者和高反应者之间的F1杂种表现出反应性的显性但缺乏互补作用。当允许BALB/c（KdIdDd）低反应性胎肝干细胞在经辐照的高反应性受体C3H.OH（KdIdDk）中成熟时，源自BALB/c的Tc细胞可产生对Dk加SIN的反应。这一结果，连同F1杂种中缺乏互补作用，意味着低反应性的损伤在于病毒抗原无法与除H-2Dk之外的任何自身H-2K或H-2D分子（所测试的那些）结合刺激Tc细胞反应。讨论了与这些数据相符的假说。

相似文献

1
H-2-linked control of cytotoxic T-cell responsiveness to alphavirus infection. Presence of H-2Dk during differentiation and stimulation converts stem cells of low responder genotype to T cells of responder phenotype.H-2相关的细胞毒性T细胞对甲病毒感染反应性的调控。在分化和刺激过程中H-2Dk的存在将低反应基因型的干细胞转化为反应表型的T细胞。
J Exp Med. 1979 Mar 1;149(3):786-90. doi: 10.1084/jem.149.3.786.
2
H-2 complementation in anti-H-Y cytotoxic T-cell responses can occur in chimeric mice.抗H-Y细胞毒性T细胞反应中的H-2互补可在嵌合小鼠中发生。
Proc Natl Acad Sci U S A. 1978 Dec;75(12):6207-10. doi: 10.1073/pnas.75.12.6207.
3
Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness.H-2复合体中的Ir基因调控抗病毒细胞毒性T细胞的产生。定位到K或D以及无反应性的显性现象。
J Exp Med. 1978 Aug 1;148(2):592-606. doi: 10.1084/jem.148.2.592.
4
Inability of mice to generate cytotoxic T lymphocytes to vesicular stomatitis virus restricted to H-2Kk or H-2Dk.小鼠无法产生针对局限于H-2Kk或H-2Dk的水疱性口炎病毒的细胞毒性T淋巴细胞。
J Immunol. 1981 Feb;126(2):446-51.
5
Regulation of T-cell-mediated lympholysis by the murine major histocompatibility complex. I. Preferential in vitro responses to trinitrophenyl-modified self K- and D-coded gene products in parental and F1 hybrid mouse strains.小鼠主要组织相容性复合体对T细胞介导的淋巴细胞溶解的调节。I. 亲代和F1杂交小鼠品系对三硝基苯基修饰的自身K和D编码基因产物的体外优先反应。
J Exp Med. 1979 Jun 1;149(6):1379-92. doi: 10.1084/jem.149.6.1379.
6
Patterns of virus-immune T-cell responsiveness. Comparison of (H-2k X H-2b) leads to H-2b radiation chimeras and negatively selected H-2b lymphocytes.病毒免疫T细胞反应模式。（H-2k×H-2b）与H-2b辐射嵌合体及阴性选择的H-2b淋巴细胞的比较。
J Exp Med. 1979 Nov 1;150(5):1187-94. doi: 10.1084/jem.150.5.1187.
7
Low responsiveness to Dk or Db plus vaccinia virus or to Kk plus lymphocytic choriomeningitis virus assessed by availability of D or K products.根据D或K产物的可获得性评估，对Dk或Db加痘苗病毒或对Kk加淋巴细胞性脉络丛脑膜炎病毒的低反应性。
Tissue Antigens. 1981 May;17(5):507-17. doi: 10.1111/j.1399-0039.1981.tb00738.x.
8
Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.主要组织相容性复合体相关的免疫反应性是由低反应性小鼠的淋巴细胞在高反应性小鼠的胸腺中分化而获得的。
Proc Natl Acad Sci U S A. 1978 May;75(5):2439-42. doi: 10.1073/pnas.75.5.2439.
9
The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression.H-2连锁基因在辅助性T细胞功能中的作用。IV. T细胞基因型和宿主环境在I区及Ir基因表达中的重要性。
J Exp Med. 1978 Dec 1;148(6):1510-22. doi: 10.1084/jem.148.6.1510.
10
Involvement of the K and I regions of the H-2 complex in resistance to hemopoietic allografts.H-2复合体的K区和I区参与对造血异体移植物的抗性。
J Exp Med. 1984 Apr 1;159(4):1070-82. doi: 10.1084/jem.159.4.1070.

引用本文的文献

1
MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies.MHC II 类-α链敲除小鼠支持病毒复制增加，这与其 MHC II 类细胞表面表达缺失和相关免疫功能缺陷无关。
PLoS One. 2013 Jun 28;8(6):e68458. doi: 10.1371/journal.pone.0068458. Print 2013.
2
Alphavirus-specific cytotoxic T lymphocytes recognize a cross-reactive epitope from the capsid protein and can eliminate virus from persistently infected macrophages.甲病毒特异性细胞毒性T淋巴细胞识别来自衣壳蛋白的交叉反应表位，并可从持续感染的巨噬细胞中清除病毒。
J Virol. 1998 Jun;72(6):5146-53. doi: 10.1128/JVI.72.6.5146-5153.1998.
3
H-2 expression by lymphoid cells of different mouse strains: quantitative interaction of H-2 with monoclonal antibodies and their Fab fragments.不同小鼠品系淋巴细胞的H-2表达：H-2与单克隆抗体及其Fab片段的定量相互作用。
Immunology. 1981 Feb;42(2):207-15.
4
Quantitative variation in H-2-antigen expression. I. Estimation of H-2K and H-2D expression in different strains of mice.H-2抗原表达的定量变异。I. 不同品系小鼠中H-2K和H-2D表达的估计。
Immunogenetics. 1980;11(3):225-39. doi: 10.1007/BF01567790.
5
Neonatal tolerance of major histocompatibility complex antigens alters Ir gene control of the cytotoxic T cell response to vaccinia virus.主要组织相容性复合体抗原的新生儿耐受性改变了Ir基因对细胞毒性T细胞针对痘苗病毒反应的控制。
J Exp Med. 1983 Apr 1;157(4):1324-38. doi: 10.1084/jem.157.4.1324.
6
Influence of the major histocompatibility complex on the repertoire of allospecific cytolytic T lymphocytes.主要组织相容性复合体对同种特异性细胞溶解T淋巴细胞库的影响。
J Exp Med. 1982 Feb 1;155(2):380-9. doi: 10.1084/jem.155.2.380.
7
Anti-influenza virus cytotoxic T lymphocytes recognize the three viral polymerases and a nonstructural protein: responsiveness to individual viral antigens is major histocompatibility complex controlled.抗流感病毒细胞毒性T淋巴细胞识别三种病毒聚合酶和一种非结构蛋白：对单个病毒抗原的反应性受主要组织相容性复合体控制。
J Virol. 1987 Apr;61(4):1098-102. doi: 10.1128/JVI.61.4.1098-1102.1987.
8
Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen.在对H-Y抗原的细胞毒性反应中，辅助性细胞和杀伤性细胞的不同免疫应答基因。
J Exp Med. 1979 Nov 1;150(5):1134-42. doi: 10.1084/jem.150.5.1134.

本文引用的文献

1
Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex.H-2复合体K和D区域中针对病毒感染靶细胞的细胞毒性所需的基因。
Nature. 1975 Mar 20;254(5497):269-70. doi: 10.1038/254269a0.
2
H-2 complementation in anti-H-Y cytotoxic T-cell responses can occur in chimeric mice.抗H-Y细胞毒性T细胞反应中的H-2互补可在嵌合小鼠中发生。
Proc Natl Acad Sci U S A. 1978 Dec;75(12):6207-10. doi: 10.1073/pnas.75.12.6207.
3
Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.主要组织相容性复合体相关的免疫反应性是由低反应性小鼠的淋巴细胞在高反应性小鼠的胸腺中分化而获得的。
Proc Natl Acad Sci U S A. 1978 May;75(5):2439-42. doi: 10.1073/pnas.75.5.2439.
4
H-2 gene complementation in cytotoxic T cell responses of female against male cells.雌性对雄性细胞的细胞毒性T细胞反应中的H-2基因互补作用。
Eur J Immunol. 1977 Jul;7(7):443-7. doi: 10.1002/eji.1830070708.
5
Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness.H-2复合体中的Ir基因调控抗病毒细胞毒性T细胞的产生。定位到K或D以及无反应性的显性现象。
J Exp Med. 1978 Aug 1;148(2):592-606. doi: 10.1084/jem.148.2.592.
6
Exclusive involvement of H-2Db or H-2Kd product in the interaction between T-killer lymphocytes and syngeneic H-2b or H-2d viral lymphomas.H-2Db或H-2Kd产物在杀伤性T淋巴细胞与同基因H-2b或H-2d病毒性淋巴瘤之间相互作用中的特异性参与。
J Exp Med. 1977 Oct 1;146(4):909-22. doi: 10.1084/jem.146.4.909.
7
Mechanisms of the H-2 effect on viral leukemogenesis.H-2对病毒性白血病发生影响的机制。
Scand J Immunol. 1977;6(5):533-9. doi: 10.1111/j.1365-3083.1977.tb02117.x.
8
In irradiation chimeras, K or D regions of the chimeric host, not of the donor lymphocytes, determine immune responsiveness of antiviral cytotoxic T cells.在辐射嵌合体中，嵌合宿主而非供体淋巴细胞的K或D区域决定了抗病毒细胞毒性T细胞的免疫反应性。
J Exp Med. 1978 Sep 1;148(3):805-10. doi: 10.1084/jem.148.3.805.
9
Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype.感染流感病毒和痘苗病毒的小鼠体内的细胞毒性T细胞反应强度因H-2基因型而异。
J Exp Med. 1978 Aug 1;148(2):534-43. doi: 10.1084/jem.148.2.534.
10
Responsiveness to HY antigen Ir gene complementation and target cell specificity.对HY抗原Ir基因互补作用和靶细胞特异性的反应性。
Immunol Rev. 1977;35:59-75. doi: 10.1111/j.1600-065x.1977.tb00235.x.