Gasser R B, Newton S E
Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria, Australia.
Int J Parasitol. 2000 Apr 10;30(4):509-34. doi: 10.1016/s0020-7519(00)00021-7.
Molecular genetic research on parasitic nematodes (order Strongylida) is of major significance for many fundamental and applied areas of medical and veterinary parasitology. The advent of gene technology has led to some progress for this group of nematodes, particularly in studying parasite systematics, drug resistance and population genetics, and in the development of diagnostic assays and the characterisation of potential vaccine and drug targets. This paper gives an account of the molecular biology and genetics of strongylid nematodes, mainly of veterinary socio-economic importance, indicates the implications of such research and gives a perspective on genome research for this important parasite group, in light of recent technological advances and knowledge of the genomes of other metazoan organisms.
对寄生线虫（圆线目）的分子遗传学研究在医学和兽医寄生虫学的许多基础及应用领域都具有重要意义。基因技术的出现为这类线虫带来了一些进展，特别是在寄生虫系统学、耐药性和群体遗传学研究方面，以及在诊断检测方法的开发和潜在疫苗及药物靶点的表征方面。本文介绍了主要具有兽医社会经济重要性的圆线目线虫的分子生物学和遗传学，指出了此类研究的意义，并根据最近的技术进展和对其他后生动物基因组的了解，对这一重要寄生虫群体的基因组研究进行了展望。
