Brenner S E, Levitt M
Department of Structural Biology, Stanford University, California 94305-5126, USA.
Protein Sci. 2000 Jan;9(1):197-200. doi: 10.1110/ps.9.1.197.
Structural genomics projects aim to provide an experimental structure or a good model for every protein in all completed genomes. Most of the experimental work for these projects will be directed toward proteins whose fold cannot be readily recognized by simple sequence comparison with proteins of known structure. Based on the history of proteins classified in the SCOP structure database, we expect that only about a quarter of the early structural genomics targets will have a new fold. Among the remaining ones, about half are likely to be evolutionarily related to proteins of known structure, even though the homology could not be readily detected by sequence analysis.
结构基因组学项目旨在为所有已完成测序的基因组中的每一种蛋白质提供一个实验性结构或一个良好的模型。这些项目的大部分实验工作将针对那些通过与已知结构的蛋白质进行简单序列比对无法轻易识别其折叠方式的蛋白质。根据SCOP结构数据库中已分类蛋白质的历史情况，我们预计早期结构基因组学目标中只有约四分之一会具有新的折叠方式。在其余的目标中，约有一半可能在进化上与已知结构的蛋白质相关，尽管通过序列分析无法轻易检测到这种同源性。
