Calabrese E J, Baldwin L A
Department of Environmental Health Sciences, School of Public Health, N 344 Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA.
Hum Exp Toxicol. 2000 Jan;19(1):41-75. doi: 10.1191/096032700678815602.
This paper represents the first systematic effort to describe the historical foundations of radiation hormesis. Spanning the years from 1898 to the early 1940's the paper constructs and assesses the early history of such research and evaluates how advances in related scientific fields affected the course of hormetic related research. The present effort was designed to not only address this gap in current knowledge, but to offer a toxicological basis for how the concept of hormetic dose-response relationships may affect the nature of the bioassay and its role in the risk assessment process.
本文首次系统地阐述了辐射兴奋效应的历史根源。该论文跨越了从1898年到20世纪40年代早期的时间跨度，构建并评估了此类研究的早期历史，并评估了相关科学领域的进展如何影响兴奋效应相关研究的进程。当前的研究不仅旨在填补现有知识的这一空白，还为兴奋剂量反应关系的概念如何影响生物测定的性质及其在风险评估过程中的作用提供毒理学依据。
