爱泼斯坦-巴尔病毒及其与人类癌症的关联。
The Epstein-Barr virus and its association with human cancers.
作者信息
Baumforth K R, Young L S, Flavell K J, Constandinou C, Murray P G
机构信息
Biomedical Research Laboratories, School of Health Sciences, University of Wolverhampton, UK.
出版信息
Mol Pathol. 1999 Dec;52(6):307-22. doi: 10.1136/mp.52.6.307.
Abstract
The Epstein-Barr virus (EBV) has been linked to the development of a variety of human malignancies, including Burkitt's lymphoma, Hodgkin's disease, nasopharyngeal carcinoma, some T cell lymphomas, post-transplant lymphoproliferative disease, and more recently, certain cancers of the stomach and smooth muscle. This review summarizes these associations and in particular the role of the viral latent genes in the transformation process.
摘要
爱泼斯坦-巴尔病毒（EBV）与多种人类恶性肿瘤的发生有关，包括伯基特淋巴瘤、霍奇金病、鼻咽癌、某些T细胞淋巴瘤、移植后淋巴细胞增殖性疾病，以及最近发现的某些胃癌和平滑肌肉癌。本综述总结了这些关联，特别是病毒潜伏基因在转化过程中的作用。
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本文引用的文献
1
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J Natl Cancer Inst. 1999 Aug 18;91(16):1376-81. doi: 10.1093/jnci/91.16.1376.
2
Effect of material deprivation on Epstein-Barr virus infection in Hodgkin's disease in the West Midlands.西米德兰兹郡霍奇金淋巴瘤中物质剥夺对爱泼斯坦-巴尔病毒感染的影响
Br J Cancer. 1999 May;80(3-4):604-8. doi: 10.1038/sj.bjc.6690398.
3
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EMBO J. 1999 Jun 1;18(11):3064-73. doi: 10.1093/emboj/18.11.3064.
4
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J Biol Chem. 1999 Jun 4;274(23):16085-96. doi: 10.1074/jbc.274.23.16085.
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6
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7
8
9
Epstein-Barr virus and Hodgkin's disease: further evidence for the three disease hypothesis.
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10
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Annu Rev Immunol. 1998;16:293-322. doi: 10.1146/annurev.immunol.16.1.293.
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