Devinsky O, Perrine K, Hirsch J, McMullen W, Pacia S, Doyle W
Departments of Neurology, Neurosurgery & Psychiatry, NYU School of Medicine, New York, New York, USA.
Epilepsia. 2000 Apr;41(4):400-4. doi: 10.1111/j.1528-1157.2000.tb00180.x.
To investigate the relation between the number and spatial distribution of language sites and specific patient-and epilepsy-related variables.
Patients with stimulation-induced reading or naming errors from anterior or inferior temporal cortex (i.e., atypical temporal language sites) were compared with those with language sites confined to Wernicke's area (WA) in the posterosuperior temporal and inferior parietal perisylvian area. In a consecutive series of 44 left hemisphere language dominant patients with complex partial seizures before left temporal lobectomy, correlations were compared between cortical language distribution and measures of cognitive function.
Patients with atypical temporal language sites (group 1) had significantly fewer years of education that did patients with language sites in WA (group 2). Patients in group 1 had poorer verbal learning and fluency than did patients in group 2. Patients with IQ <80 were significantly more likely to have multiple sites where stimulation disrupted language than did patients with normal IQ. Number of language sites had significant negative correlations with full-scale IQ, and measures of confrontation naming, verbal fluency, and immediate verbal memory.
Language cortex has a wider spatial distribution in epilepsy surgery patients with lower intelligence, poorer education, and worse verbal and memory skills.
研究语言区的数量和空间分布与特定患者及癫痫相关变量之间的关系。
将因刺激导致颞叶前部或下部皮质（即非典型颞叶语言区）出现阅读或命名错误的患者，与语言区局限于颞叶后上部和顶叶下部岛周区韦尼克区（WA）的患者进行比较。在连续的44例左侧半球语言优势、术前有复杂部分性发作的患者行左侧颞叶切除术前，比较皮质语言分布与认知功能指标之间的相关性。
非典型颞叶语言区患者（第1组）的受教育年限显著少于语言区位于WA的患者（第2组）。第1组患者的言语学习能力和流畅性比第2组患者差。智商<80的患者比智商正常的患者更有可能有多个刺激会干扰语言的区域。语言区数量与全量表智商、对答命名、言语流畅性和即时言语记忆指标呈显著负相关。
在智力较低、受教育程度较差以及言语和记忆技能较差的癫痫手术患者中，语言皮质的空间分布更广。
