Baronzio G, Zambelli A, Comi D, Barlocco A, Baronzio A, Marchesi P, Gramaglia A, Castiglioni E, Mafezzoni A, Beviglia E, Crespi F, Cargnel A I, Pravettoni G
Hyperthermia and Oncology Session, Centri Clinici Chirurgici Padre Pio, Va, Italy.
In Vivo. 1999 Nov-Dec;13(6):499-502.
The serum concentrations of inflammatory (Interleukin-1 beta, Tumor necrosis alpha, Interleukin-6) and regulatory cytokines (Interleukin twelve) have been studied in ten AIDS cachectic patients and compared to a control group. A cytokine imbalance, and peculiarly a significant increase in proinflammatory cytokines (Interleukin-1, Interleukin-6, Tumor necrosis Factor alpha) and a decrease in regulatory cytokines such as Interleukin-12 were found. A significant correlation resulted between weight loss and Interleukin-1 beta and 6. A negative correlation between Interleukin-1 and 12 was noted, indicating that this last cytokine has an important regulatory role also in advanced state of the disease.
对10例艾滋病恶病质患者的炎症性细胞因子（白细胞介素-1β、肿瘤坏死因子α、白细胞介素-6）和调节性细胞因子（白细胞介素12）的血清浓度进行了研究，并与对照组进行了比较。发现细胞因子失衡，特别是促炎细胞因子（白细胞介素-1、白细胞介素-6、肿瘤坏死因子α）显著增加，而调节性细胞因子如白细胞介素-12减少。体重减轻与白细胞介素-1β和白细胞介素-6之间存在显著相关性。白细胞介素-1和白细胞介素-12之间存在负相关，表明后者在疾病晚期也具有重要的调节作用。
