Cheung W Y, Garratt A M, Russell I T, Williams J G
School of Postgraduate Studies in Medical & Health Care, Maes-y-Gwernen Hall, Morriston Hospital, Swansea, UK.
J Clin Epidemiol. 2000 Mar 1;53(3):297-306. doi: 10.1016/s0895-4356(99)00152-3.
Measurement of health-related quality of life (HRQL) is becoming more important in studies of patients with inflammatory bowel disease. The McMaster IBDQ is the most widely used HRQL instrument for these patients. However, its use with patients in the United Kingdom has not been validated. This study develops and validates a UK version of the McMaster IBDQ (UK IBDQ). The UK IBDQ was tested with two samples of patients for its reliability, validity, reproducibility, and responsiveness. The first sample consisted of 180 patients participating in a randomized clinical trial. The second was recruited from members of the National Association for Colitis and Crohns Disease. Reliability of the subscales and the summary score of the UK IBDQ is demonstrated by Cronbach's alpha and item-total correlations. Their validity is demonstrated by their correlations with SF-36 subscales and an empirical index of disease activity. Good intraclass correlations and responsiveness ratios show their reproducibility and responsiveness. The findings support the reliability, validity, reproducibility, and responsiveness of the UK IBDQ and its acceptability to patients in UK.
在炎症性肠病患者的研究中，与健康相关的生活质量（HRQL）测量正变得越来越重要。麦克马斯特炎症性肠病问卷（McMaster IBDQ）是这些患者中使用最广泛的HRQL工具。然而，其在英国患者中的使用尚未得到验证。本研究开发并验证了麦克马斯特炎症性肠病问卷的英国版本（UK IBDQ）。对UK IBDQ在两组患者样本中进行了可靠性、有效性、可重复性和反应性测试。第一个样本由180名参与随机临床试验的患者组成。第二个样本是从全国结肠炎和克罗恩病协会的成员中招募的。UK IBDQ分量表和总评分的可靠性通过克朗巴哈系数（Cronbach's alpha）和项目与总分的相关性得以证明。它们的有效性通过与SF-36分量表的相关性以及疾病活动的经验指数得以证明。良好的组内相关性和反应率显示了它们的可重复性和反应性。这些发现支持了UK IBDQ的可靠性、有效性、可重复性和反应性及其在英国患者中的可接受性。
