Aureli T, Di Cocco M E, Capuani G, Ricciolini R, Manetti C, Miccheli A, Conti F
Department of Biochemistry, Sigma-Tau Labs, Pomezia, Italy.
Neurochem Res. 2000 Mar;25(3):395-9. doi: 10.1023/a:1007501306623.
Changes in brain lipid composition have been determined in 24 months-old Fischer rats with respect to 6 months-old ones. The cerebral levels of sphingomyelin and cholesterol were found to be significantly increased in aged rats, whereas the amount of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, and phosphatidic acid appear to be unaffected by aging. Long-term feeding with acetyl-L-carnitine was able to reduce the age-dependent increase of both sphingomyelin and cholesterol cerebral levels with no effect on the other measured phospholipids. These findings shown that changes in membrane lipid metabolism and/or composition represent one of the alterations occurring in rat brain with aging, and that long-term feeding with acetyl-L-carnitine can be useful in normalizing these age-dependent disturbances.
已对24月龄的费希尔大鼠与6月龄大鼠的脑脂质组成变化进行了测定。结果发现，老年大鼠脑中鞘磷脂和胆固醇水平显著升高，而磷脂酰胆碱、磷脂酰乙醇胺、磷脂酰丝氨酸、磷脂酰肌醇和磷脂酸的含量似乎不受衰老影响。长期喂食乙酰-L-肉碱能够降低鞘磷脂和胆固醇脑水平随年龄增长的升高，而对其他测定的磷脂没有影响。这些发现表明，膜脂质代谢和/或组成的变化是大鼠脑随衰老发生的改变之一，并且长期喂食乙酰-L-肉碱有助于使这些与年龄相关的紊乱恢复正常。
