Wilks M F
Medical Toxicology Unit, Guy's & St. Thomas' Hospital Trust, London, United Kingdom.
J Toxicol Clin Toxicol. 2000;38(2):103-5. doi: 10.1081/clt-100100923.
Pyrethroid-induced paresthesia is frequently seen after dermal exposure to pyrethroids. Affected individuals experience a sensation of burning, tingling, itching, or numbness, most commonly in the face. This occurs 1-2 hours after the beginning of exposure and resolves spontaneously.
Paresthesia occurs as a result of a direct effect on intracutaneous nerve endings at very low pyrethroid doses. It is related to potency of the pyrethroid with pyrethroids without an alpha-cyano group generally showing the weakest effect.
Doses sufficient to cause paresthesia are far lower than those causing central or systemic toxicity. Paresthesia is therefore considered to be a localized nuisance effect. The best advice to affected individuals is to prevent paresthesia from occurring through appropriate hygiene measures and personal protection.
拟除虫菊酯引起的感觉异常在皮肤接触拟除虫菊酯后很常见。受影响的个体通常会在面部出现灼烧、刺痛、瘙痒或麻木的感觉。这种情况在接触开始后1至2小时出现，并会自行缓解。
感觉异常是由于拟除虫菊酯在极低剂量下对皮内神经末梢产生直接作用所致。它与拟除虫菊酯的效力有关，一般来说，没有α-氰基的拟除虫菊酯作用最弱。
足以引起感觉异常的剂量远低于引起中枢或全身毒性的剂量。因此，感觉异常被认为是一种局部的不良影响。对于受影响的个体，最好的建议是通过适当的卫生措施和个人防护来预防感觉异常的发生。
