Berman A E, Kozlova N I
Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow.
Membr Cell Biol. 2000;13(2):207-44.
Integrins are cell surface transmembrane glycoproteins which perform receptor functions in cell interactions with the extracellular matrix and cell-cell contacts. Another function of integrins is transduction of signals which mediate the effects of the matrix on the physiological activity of cells (motility, proliferation, differentiation, etc.). Contemporary views on the molecular structure of integrins and their involvement in the organization of the cytoskeleton and control of gene activity are presented. Biochemical mechanisms, by which the signal functions of integrins are realized, are discussed. The data on the participation of integrins in oncogenic cell transformation, metastasis, and apoptosis are analyzed.
整合素是细胞表面跨膜糖蛋白，在细胞与细胞外基质的相互作用以及细胞间接触中发挥受体功能。整合素的另一个功能是信号转导，介导基质对细胞生理活性（运动、增殖、分化等）的影响。文中介绍了关于整合素分子结构及其参与细胞骨架组织和基因活性调控的当代观点。讨论了整合素信号功能得以实现的生化机制。分析了整合素参与致癌细胞转化、转移和凋亡的相关数据。
