Research Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Islamic Republic of Iran.
Pharmaceutical Research Institute, 8 Rydygiera Street, 01-793, Warsaw, Poland.
Sci Rep. 2021 Mar 1;11(1):4820. doi: 10.1038/s41598-021-84209-6.
A library of new spiro[diindeno[1,2-b:2',1'-e]pyridine-11,3'-indoline]-2',10,12-trione derivatives has been prepared in an efficient, one-pot pseudo four-component method mediated by a reusable heterogeneous nano-ordered mesoporous SOH functionalized-silica (MCM-41-SOH) catalyst. Excellent yields, short reaction times, as well as convenient non-chromatographic purification of the products and environmental benefits such as green and metal-free conditions constitute the main advantages of the developed synthetic methodology. The obtained fused indole-indenone dyes would be of interest to pharmaceutical and medicinal chemistry. Furthermore, due to their sensitivity to pH changes, they could be used as novel pH indicators.
已通过可重复使用的非均相纳米有序介孔 SOH 功能化硅（MCM-41-SOH）催化剂，以高效、一锅法准四级反应，制备了新型螺[二茚并[1,2-b:2',1'-e]吡啶-11,3'-吲哚啉]-2',10,12-三酮衍生物库。该合成方法的主要优点包括：高产率、短反应时间、产品无需色谱纯化、环境友好（绿色、无金属）。所得到的稠合吲哚-茚满二酮染料可能对药物和药物化学具有重要意义。此外，由于它们对 pH 值变化敏感，因此可作为新型 pH 指示剂。
