来自红叶风车子的生物活性化合物。

Bioactive compounds from Combretum erythrophyllum.

作者信息

Schwikkard S, Zhou B N, Glass T E, Sharp J L, Mattern M R, Johnson R K, Kingston D G

机构信息

Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0212, USA.

出版信息

J Nat Prod. 2000 Apr;63(4):457-60. doi: 10.1021/np9904410.

DOI:10.1021/np9904410

PMID:10785413

Abstract

A methanol extract of Combretum erythrophyllum showed inhibitory bioactivities in a yeast-based microtiter assay for DNA-damaging agents. Bioassay-guided fractionation of this extract yielded two known bioactive compounds, combretastatin A-1 and (-)-combretastatin, and two new bioactive glucosides, combretastatin A-1 2'-beta-D-glucoside (1) and combretastatin B-1 2'-beta-D-glucoside (2). The structures of the new compounds were assigned by (1)H and (13)C NMR, DEPT, HMQC, and HMBC spectra.

摘要

在一项基于酵母的微量滴定法检测DNA损伤剂的实验中，红木叶风车子的甲醇提取物显示出抑制生物活性。对该提取物进行生物测定导向的分级分离，得到了两种已知的生物活性化合物，即柯桠素A-1和（-）-柯桠素，以及两种新的生物活性糖苷，柯桠素A-1 2'-β-D-葡萄糖苷（1）和柯桠素B-1 2'-β-D-葡萄糖苷（2）。通过¹H和¹³C NMR、DEPT、HMQC和HMBC光谱确定了新化合物的结构。