Maia D M, Dorfman R F
Department of Pathology, Stanford University Medical Center, CA 94305, USA.
Hum Pathol. 1995 Dec;26(12):1378-82. doi: 10.1016/0046-8177(95)90305-4.
Sinus histiocytosis with massive lymphadenopathy (SHML/Rosai-Dorfman disease) has, on rare occasions been identified as an isolated phenomenon in lymph nodes affected by malignant lymphomas. The Registry includes four cases of SHML in patients with non-Hodgkin's lymphomas and one with multiple myeloma. SHML has more recently been recorded as a focal finding in lymph nodes involved by Hodgkin's disease of the mixed cellularity type. We report two patients presenting with lymphadenopathy caused by involvement by nodular lymphocyte predominant Hodgkin's disease with focal changes of SHML, an association not previously recorded in the literature. Responsiveness of the histiocytic cells of SHML to B-cell derived cytokines is postulated as a mechanism for this phenomenon, an hypothesis previously raised in regard to the association of focal Langerhans cell histiocytosis with Hodgkin's disease and with non-Hodgkin's lymphomas.
伴有巨大淋巴结病的窦性组织细胞增生症（SHML/罗萨伊-多夫曼病）在极少数情况下被确定为受恶性淋巴瘤影响的淋巴结中的一种孤立现象。该登记处包括4例非霍奇金淋巴瘤患者的SHML病例和1例多发性骨髓瘤患者的SHML病例。最近，SHML被记录为混合细胞型霍奇金病累及淋巴结的局灶性表现。我们报告了2例由结节性淋巴细胞为主型霍奇金病累及并伴有SHML局灶性改变引起淋巴结病的患者，这种关联以前在文献中未被记录。SHML的组织细胞对B细胞衍生细胞因子的反应性被假定为这一现象的一种机制，这一假说先前在局灶性朗格汉斯细胞组织细胞增生症与霍奇金病及非霍奇金淋巴瘤的关联中也曾被提出。
