Axmon A, Rylander L, Strömberg U, Hagmar L
Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, Lund, Sweden.
Int Arch Occup Environ Health. 2000 Apr;73(3):204-8. doi: 10.1007/s004200050028.
The purpose of the present study was to assess the effect, on miscarriages and stillbirths, of persistent organochlorine compounds (POC) through dietary intake of fatty fish from the Baltic Sea.
Information on miscarriages and stillbirths was collected retrospectively by a self-administered questionnaire in a cohort of fishermen's wives from the Swedish east coast (by the Baltic Sea) and in a referent cohort of west coast fishermen's wives. Current fish consumption was used as a proxy for exposure within the east coast cohort.
No increase in miscarriages or stillbirths was found in the east coast cohort compared with the west coast group, in fact a decrease in early miscarriages was found (OR 0.48 [95% CI 0.26-0.92]). Moreover, no increase in risk was found for current high consumers of fatty fish within the east coast cohort.
The present data provided no evidence that dietary POC exposure increases miscarriage and stillbirth rates.
本研究旨在评估通过食用来自波罗的海的富含脂肪的鱼类而摄入持久性有机氯化合物（POC）对流产和死产的影响。
通过自我填写问卷，对来自瑞典东海岸（波罗的海沿岸）渔民妻子队列以及西海岸渔民妻子对照队列的流产和死产信息进行回顾性收集。东海岸队列中当前的鱼类消费量被用作接触POC的替代指标。
与西海岸组相比，东海岸队列中流产或死产没有增加，实际上早期流产有所减少（比值比0.48 [95%可信区间0.26 - 0.92]）。此外，东海岸队列中当前大量食用富含脂肪鱼类的人群风险也没有增加。
目前的数据没有提供证据表明通过饮食接触POC会增加流产率和死产率。
