Cornere B M, Menzies R
N Z Med J. 1975 Mar 26;81(536):292-4.
Over a period of five months Haemophilus influenzae isolated from 123 patients were tested for resistance to co-trimoxazole and trimethoprim by the disc method of sensitivity testing and isolates from four patients were found to be resistant. However, the minimum inhibitory concentrations of trimethoprim lactate were estimated for the isolates from these four patients only one was found to be resistant. This H. influenzae strain was from one of the two patients in the survey who had a history of repeated courses of co-trimoxazole therapy. The discrepancy between the results of the disc sensitivity tests and the minimum inhibitory concentration estimations of the resistance of H. influenzae to co-trimoxazole and trimethoprim. The appearance of co-trimoxazole and trimethoprim resistance in H. influenzae isolated from a patient who has had prolonged treatment with co-trimoxazole is in agreement with the findings of other authors.
在五个月的时间里，采用纸片法药敏试验对从123例患者中分离出的流感嗜血杆菌进行了复方新诺明和甲氧苄啶耐药性检测，发现有4例患者的分离株耐药。然而，仅对这4例患者的分离株测定了乳酸甲氧苄啶的最低抑菌浓度，仅发现1株耐药。该流感嗜血杆菌菌株来自调查中两名有反复使用复方新诺明治疗史的患者之一。流感嗜血杆菌对复方新诺明和甲氧苄啶耐药性的纸片药敏试验结果与最低抑菌浓度测定结果之间存在差异。从长期接受复方新诺明治疗的患者中分离出的流感嗜血杆菌出现复方新诺明和甲氧苄啶耐药，这与其他作者的研究结果一致。
